Nanobodies Provide Insight into the Molecular Mechanisms of the Complement Cascade and Offer New Therapeutic Strategies.

Zarantonello, Alessandra; Pedersen, Henrik; Laursen, Nick S; Andersen, Gregers R

Zarantonello, Alessandra; Pedersen, Henrik; Laursen, Nick S; Andersen, Gregers R.

Affiliation

Zarantonello A; Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus, Denmark.
Pedersen H; Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus, Denmark.
Laursen NS; Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark.
Andersen GR; Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus, Denmark.

Biomolecules ; 11(2)2021 02 17.

Article in En | MEDLINE | ID: mdl-33671302

Subject(s)

Complement Activation; Complement System Proteins; Nanomedicine/methods; Single-Domain Antibodies/chemistry; Animals; Antibodies, Monoclonal, Humanized/therapeutic use; Atypical Hemolytic Uremic Syndrome/drug therapy; Atypical Hemolytic Uremic Syndrome/immunology; Complement C1/chemistry; Complement C3-C5 Convertases/chemistry; Epitopes/chemistry; Hemoglobinuria, Paroxysmal/drug therapy; Hemoglobinuria, Paroxysmal/immunology; Humans; Immunity, Innate; Immunoglobulin G/immunology; Inflammation; Molecular Conformation; Protein Binding; Proteolysis

Key words

complement system; convertase; inhibitor; molecular mechanism; proteolytic cascade; structural biology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Complement System Proteins / Complement Activation / Nanomedicine / Single-Domain Antibodies Limits: Animals / Humans Language: En Journal: Biomolecules Year: 2021 Document type: Article

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