The effect of the platelet-rich plasma and ozone therapy on tendon-to-bone healing in the rabbit rotator cuff repair model.
J Orthop Surg Res
; 16(1): 202, 2021 Mar 19.
Article
in En
| MEDLINE
| ID: mdl-33740995
ABSTRACT
BACKGROUND:
The aim of this study is to histologically and biomechanically investigate the effects of local PRP and ozone therapy (O2O3) on tendon-to-bone healing in a rabbit model of the supraspinatus tendon tear.METHODS:
Four groups were formed to have seven rabbits in each group repair, R; repair + PRP, RP; repair + ozone, RO; and repair + PRP + ozone, RPO. The supraspinatus tendon was detached by sharp dissection from the footprint and an acute tear pattern was created. Thereafter, tendon repair was performed with the transosseous technique. In the RP group, PRP, and in the RPO group, PRP + O2O3 mixture was injected to the tendon repair site. In the RO group, O2O3 gas mixture was injected into subacromial space three times a week for a total of 4 weeks. The study was ended at postoperative 6th week.RESULTS:
When compared with the R group, a statistically significant increase was observed in the biomechanical strength of the RP and RPO groups. The highest increase in biomechanical strength was detected in the RPO group. The histology of the RO and RPO groups showed better collagen fiber continuity and orientation than the R and RP groups.CONCLUSIONS:
The results obtained from this study show that the ozonized PRP can be used as biological support to increase tendon-to-bone healing. However, these results need to be supported by clinical studies.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ozone
/
Tendons
/
Wound Healing
/
Bone and Bones
/
Rotator Cuff
/
Platelet-Rich Plasma
/
Rotator Cuff Injuries
Limits:
Animals
Language:
En
Journal:
J Orthop Surg Res
Year:
2021
Document type:
Article