ICOSL in host defense at epithelial barriers: lessons from ICOSLG deficiency.
Curr Opin Immunol
; 72: 21-26, 2021 10.
Article
in En
| MEDLINE
| ID: mdl-33756276
Autosomal recessive mutations in Inducible T Cell Costimulator Ligand (ICOSLG) result in a combined immunodeficiency syndrome of humans, saliently marked by recurrent respiratory tract infections and significant disease with DNA-based viruses at epithelial barriers, including human papillomavirus (HPV). These features are also seen in persons with loss of function of the complementary gene, ICOS. The infection phenotypes associated with these natural experiments disclose a critical role of the corresponding proteins, ICOSL and ICOS, in human immunity at mucocutaneous barriers. Here, we review the syndromes of ICOSL and ICOS deficiency and explore the mechanisms by which the ICOSL:ICOS axis mediates epithelial host defenses.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Epithelium
/
Host-Pathogen Interactions
/
Disease Resistance
/
Inducible T-Cell Co-Stimulator Ligand
Type of study:
Etiology_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Curr Opin Immunol
Year:
2021
Document type:
Article