Regulation of Pancreatic ß-Cell Function by the NPY System.
Endocrinology
; 162(8)2021 08 01.
Article
in En
| MEDLINE
| ID: mdl-33824978
ABSTRACT
The neuropeptide Y (NPY) system has been recognized as one of the most critical molecules in the regulation of energy homeostasis and glucose metabolism. Abnormal levels of NPY have been shown to contribute to the development of metabolic disorders including obesity, cardiovascular diseases, and diabetes. NPY centrally promotes feeding and reduces energy expenditure, while the other family members, peptide YY (PYY) and pancreatic polypeptide (PP), mediate satiety. New evidence has uncovered additional functions for these peptides that go beyond energy expenditure and appetite regulation, indicating a more extensive function in controlling other physiological functions. In this review, we will discuss the role of the NPY system in the regulation of pancreatic ß-cell function and its therapeutic implications for diabetes.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Neuropeptide Y
/
Receptors, Neuropeptide Y
/
Insulin-Secreting Cells
Limits:
Animals
/
Humans
Language:
En
Journal:
Endocrinology
Year:
2021
Document type:
Article