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Small-Molecule Natural Product Physachenolide C Potentiates Immunotherapy Efficacy by Targeting BET Proteins.
Tewary, Poonam; Brooks, Alan D; Xu, Ya-Ming; Wijeratne, E M Kithsiri; Babyak, Ashley L; Back, Timothy C; Chari, Raj; Evans, Christine N; Henrich, Curtis J; Meyer, Thomas J; Edmondson, Elijah F; de Aquino, Maria T Prudente; Kanagasabai, Thanigaivelan; Shanker, Anil; Gunatilaka, A A Leslie; Sayers, Thomas J.
Affiliation
  • Tewary P; Basic Science Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland.
  • Brooks AD; Basic Science Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland.
  • Xu YM; Southwest Center for Natural Products Research, School of Natural Resources and the Environment, College of Agriculture and Life Sciences, The University of Arizona, Tucson, Arizona.
  • Wijeratne EMK; Southwest Center for Natural Products Research, School of Natural Resources and the Environment, College of Agriculture and Life Sciences, The University of Arizona, Tucson, Arizona.
  • Babyak AL; Cancer and Inflammation Program, NCI, Frederick, Maryland.
  • Back TC; Cancer and Inflammation Program, NCI, Frederick, Maryland.
  • Chari R; Genome Modification Core Laboratory Frederick National Laboratory for Cancer Research, Frederick, Maryland.
  • Evans CN; Genome Modification Core Laboratory Frederick National Laboratory for Cancer Research, Frederick, Maryland.
  • Henrich CJ; Basic Science Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland.
  • Meyer TJ; CCR Collaborative Bioinformatics Resource, NCI, NIH, Bethesda, Maryland.
  • Edmondson EF; Advanced Biomedical Computational Science, Frederick National Laboratory for Cancer Research, Frederick, Maryland.
  • de Aquino MTP; Molecular Histopathology Laboratory, Frederick National Laboratory for Cancer Research, Frederick, Maryland.
  • Kanagasabai T; Department of Biochemistry, Cancer Biology, Neuroscience and Pharmacology, School of Medicine, Meharry Medical College, Nashville, Tennessee.
  • Shanker A; Department of Biochemistry, Cancer Biology, Neuroscience and Pharmacology, School of Medicine, Meharry Medical College, Nashville, Tennessee.
  • Gunatilaka AAL; Department of Biochemistry, Cancer Biology, Neuroscience and Pharmacology, School of Medicine, Meharry Medical College, Nashville, Tennessee.
  • Sayers TJ; Host-Tumor Interactions Research Program, Vanderbilt-Ingram Cancer Center, Nashville, Tennessee.
Cancer Res ; 81(12): 3374-3386, 2021 06 15.
Article in En | MEDLINE | ID: mdl-33837043
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Full text: 1 Collection: 01-internacional Health context: 6_ODS3_enfermedades_notrasmisibles Database: MEDLINE Main subject: Transcription Factors / Biological Products / Melanoma, Experimental / Poly I-C / Cell Cycle Proteins / Withanolides / Immunotherapy Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: Cancer Res Year: 2021 Document type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Health context: 6_ODS3_enfermedades_notrasmisibles Database: MEDLINE Main subject: Transcription Factors / Biological Products / Melanoma, Experimental / Poly I-C / Cell Cycle Proteins / Withanolides / Immunotherapy Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: Cancer Res Year: 2021 Document type: Article