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Innate lymphoid cell recovery and occurrence of GvHD after hematopoietic stem cell transplantation.
Piperoglou, Christelle; Larid, Guillaume; Vallentin, Blandine; Balligand, Laura; Crinier, Adeline; Banzet, Nathalie; Farnarier, Catherine; Gomez-Massa, Elena; Adalia, Aranzazu Cruz; Michel, Gérard; Galambrun, Claire; Barlogis, Vincent; Vivier, Eric; Vély, Frédéric.
Affiliation
  • Piperoglou C; APHM, Hôpital de la Timone, Service d'Immunologie, Marseille-Immunopole, Marseille, France.
  • Larid G; APHM, Hôpital de la Timone, Service d'Immunologie, Marseille-Immunopole, Marseille, France.
  • Vallentin B; APHM, Hôpital de la Timone, Service d'Hématologie et Oncologie Pédiatrique, Marseille, France.
  • Balligand L; APHM, Hôpital de la Timone, Service d'Hématologie et Oncologie Pédiatrique, Marseille, France.
  • Crinier A; Aix Marseille Univ, CNRS, INSERM, CIML, Marseille, France.
  • Banzet N; APHM, Hôpital de la Timone, Service d'Immunologie, Marseille-Immunopole, Marseille, France.
  • Farnarier C; APHM, Hôpital de la Timone, Service d'Immunologie, Marseille-Immunopole, Marseille, France.
  • Gomez-Massa E; Aix Marseille Univ, CNRS, INSERM, CIML, Marseille, France.
  • Adalia AC; Aix Marseille Univ, CNRS, INSERM, CIML, Marseille, France.
  • Michel G; APHM, Hôpital de la Timone, Service d'Hématologie et Oncologie Pédiatrique, Marseille, France.
  • Galambrun C; APHM, Hôpital de la Timone, Service d'Hématologie et Oncologie Pédiatrique, Marseille, France.
  • Barlogis V; APHM, Hôpital de la Timone, Service d'Hématologie et Oncologie Pédiatrique, Marseille, France.
  • Vivier E; APHM, Hôpital de la Timone, Service d'Immunologie, Marseille-Immunopole, Marseille, France.
  • Vély F; Aix Marseille Univ, CNRS, INSERM, CIML, Marseille, France.
J Leukoc Biol ; 111(1): 161-172, 2022 01.
Article in En | MEDLINE | ID: mdl-33847423
Lymphocytes are essential for microbial immunity, tumor surveillance, and tissue homeostasis. However, the in vivo development and function of helper-like innate lymphoid cells (ILCs) in humans remain much less well understood than those of T, B, and NK cells. We monitored hematopoietic stem cell transplantation (HSCT) to determine the kinetics of ILC development in both children and adults. It was found that, unlike NK cells, helper-like ILCs recovered slowly, mirroring the pattern observed for T cells, with normalization achieved at 1 year. The type of graft and the proportion of CD34+ cells in the graft did not significantly affect ILC reconstitution. As HSCT is often complicated by acute or chronic graft-versus-host disease (GVHD), the potential role of ILC subsets in maintaining tissue integrity in these conditions was also analyzed. It was found that GVHD was associated with lower levels of activated and gut-homing NKp44+ ILCP, consistent with a non-redundant role of this ILC subset in preventing this life-threatening disorder in lymphopenic conditions.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lymphocytes / Hematopoietic Stem Cell Transplantation / Graft vs Host Disease / Immunity, Innate Type of study: Observational_studies / Risk_factors_studies Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: J Leukoc Biol Year: 2022 Document type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lymphocytes / Hematopoietic Stem Cell Transplantation / Graft vs Host Disease / Immunity, Innate Type of study: Observational_studies / Risk_factors_studies Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: J Leukoc Biol Year: 2022 Document type: Article