The Mononuclear Phagocyte System of the Rat.
J Immunol
; 206(10): 2251-2263, 2021 05 15.
Article
in En
| MEDLINE
| ID: mdl-33965905
ABSTRACT
The laboratory rat continues to be the model of choice for many studies of physiology, behavior, and complex human diseases. Cells of the mononuclear phagocyte system (MPS; monocytes, macrophages, and dendritic cells) are abundant residents in every tissue in the body and regulate postnatal development, homeostasis, and innate and acquired immunity. Recruitment and proliferation of MPS cells is an essential component of both initiation and resolution of inflammation. The large majority of current knowledge of MPS biology is derived from studies of inbred mice, but advances in technology and resources have eliminated many of the advantages of the mouse as a model. In this article, we review the tools available and the current state of knowledge of development, homeostasis, regulation, and diversity within the MPS of the rat.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Rats
/
Mononuclear Phagocyte System
/
Disease Models, Animal
/
Adaptive Immunity
/
Immunity, Innate
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
J Immunol
Year:
2021
Document type:
Article