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Gut Microbiome-Derived Metabolite Trimethylamine N-Oxide Induces Aortic Stiffening and Increases Systolic Blood Pressure With Aging in Mice and Humans.
Brunt, Vienna E; Casso, Abigail G; Gioscia-Ryan, Rachel A; Sapinsley, Zachary J; Ziemba, Brian P; Clayton, Zachary S; Bazzoni, Amy E; VanDongen, Nicholas S; Richey, James J; Hutton, David A; Zigler, Melanie C; Neilson, Andrew P; Davy, Kevin P; Seals, Douglas R.
Affiliation
  • Brunt VE; From the Department of Integrative Physiology, University of Colorado Boulder (V.E.B., A.G.C., R.A.G.-R., Z.J.S., B.P.Z., Z.S.C., A.E.B., N.S.V., J.J.R., D.A.H., M.C.Z., D.R.S.).
  • Casso AG; From the Department of Integrative Physiology, University of Colorado Boulder (V.E.B., A.G.C., R.A.G.-R., Z.J.S., B.P.Z., Z.S.C., A.E.B., N.S.V., J.J.R., D.A.H., M.C.Z., D.R.S.).
  • Gioscia-Ryan RA; From the Department of Integrative Physiology, University of Colorado Boulder (V.E.B., A.G.C., R.A.G.-R., Z.J.S., B.P.Z., Z.S.C., A.E.B., N.S.V., J.J.R., D.A.H., M.C.Z., D.R.S.).
  • Sapinsley ZJ; From the Department of Integrative Physiology, University of Colorado Boulder (V.E.B., A.G.C., R.A.G.-R., Z.J.S., B.P.Z., Z.S.C., A.E.B., N.S.V., J.J.R., D.A.H., M.C.Z., D.R.S.).
  • Ziemba BP; From the Department of Integrative Physiology, University of Colorado Boulder (V.E.B., A.G.C., R.A.G.-R., Z.J.S., B.P.Z., Z.S.C., A.E.B., N.S.V., J.J.R., D.A.H., M.C.Z., D.R.S.).
  • Clayton ZS; From the Department of Integrative Physiology, University of Colorado Boulder (V.E.B., A.G.C., R.A.G.-R., Z.J.S., B.P.Z., Z.S.C., A.E.B., N.S.V., J.J.R., D.A.H., M.C.Z., D.R.S.).
  • Bazzoni AE; From the Department of Integrative Physiology, University of Colorado Boulder (V.E.B., A.G.C., R.A.G.-R., Z.J.S., B.P.Z., Z.S.C., A.E.B., N.S.V., J.J.R., D.A.H., M.C.Z., D.R.S.).
  • VanDongen NS; From the Department of Integrative Physiology, University of Colorado Boulder (V.E.B., A.G.C., R.A.G.-R., Z.J.S., B.P.Z., Z.S.C., A.E.B., N.S.V., J.J.R., D.A.H., M.C.Z., D.R.S.).
  • Richey JJ; From the Department of Integrative Physiology, University of Colorado Boulder (V.E.B., A.G.C., R.A.G.-R., Z.J.S., B.P.Z., Z.S.C., A.E.B., N.S.V., J.J.R., D.A.H., M.C.Z., D.R.S.).
  • Hutton DA; From the Department of Integrative Physiology, University of Colorado Boulder (V.E.B., A.G.C., R.A.G.-R., Z.J.S., B.P.Z., Z.S.C., A.E.B., N.S.V., J.J.R., D.A.H., M.C.Z., D.R.S.).
  • Zigler MC; From the Department of Integrative Physiology, University of Colorado Boulder (V.E.B., A.G.C., R.A.G.-R., Z.J.S., B.P.Z., Z.S.C., A.E.B., N.S.V., J.J.R., D.A.H., M.C.Z., D.R.S.).
  • Neilson AP; Department of Food Science and Technology (A.P.N.).
  • Davy KP; Now with Department of Food, Bioprocessing and Nutrition Sciences, North Carolina State University, Kannapolis (A.P.N.).
  • Seals DR; Department of Human Nutrition, Foods, and Exercise (K.P.D.), Virginia Tech, Blacksburg.
Hypertension ; 78(2): 499-511, 2021 08.
Article in En | MEDLINE | ID: mdl-33966451
ABSTRACT
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aorta / Blood Pressure / Aging / Vascular Stiffness / Methylamines Limits: Adolescent / Adult / Aged / Animals / Female / Humans / Male / Middle aged Language: En Journal: Hypertension Year: 2021 Document type: Article
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aorta / Blood Pressure / Aging / Vascular Stiffness / Methylamines Limits: Adolescent / Adult / Aged / Animals / Female / Humans / Male / Middle aged Language: En Journal: Hypertension Year: 2021 Document type: Article