Context-specific action of macrolide antibiotics on the eukaryotic ribosome.

Svetlov, Maxim S; Koller, Timm O; Meydan, Sezen; Shankar, Vaishnavi; Klepacki, Dorota; Polacek, Norbert; Guydosh, Nicholas R; Vázquez-Laslop, Nora; Wilson, Daniel N; Mankin, Alexander S

Svetlov, Maxim S; Koller, Timm O; Meydan, Sezen; Shankar, Vaishnavi; Klepacki, Dorota; Polacek, Norbert; Guydosh, Nicholas R; Vázquez-Laslop, Nora; Wilson, Daniel N; Mankin, Alexander S.

Affiliation

Svetlov MS; Center for Biomolecular Sciences, University of Illinois at Chicago, Chicago, IL, USA.
Koller TO; Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, IL, USA.
Meydan S; Institute for Biochemistry and Molecular Biology, University of Hamburg, Hamburg, Germany.
Shankar V; Center for Biomolecular Sciences, University of Illinois at Chicago, Chicago, IL, USA.
Klepacki D; Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, USA.
Polacek N; Postdoctoral Research Associate Training Program, National Institute of General Medical Sciences, National Institutes of Health, Bethesda, MD, USA.
Guydosh NR; Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland.
Vázquez-Laslop N; Center for Biomolecular Sciences, University of Illinois at Chicago, Chicago, IL, USA.
Wilson DN; Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland.
Mankin AS; Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, USA.

Nat Commun ; 12(1): 2803, 2021 05 14.

Article in En | MEDLINE | ID: mdl-33990576

Subject(s)

Anti-Bacterial Agents/pharmacology; Macrolides/pharmacology; Ribosomes/drug effects; Anti-Bacterial Agents/chemistry; Binding Sites; Cryoelectron Microscopy; Eukaryotic Cells/drug effects; Eukaryotic Cells/metabolism; Humans; Macrolides/chemistry; Models, Molecular; Mutation; Protein Binding; Protein Biosynthesis/drug effects; Protein Synthesis Inhibitors/chemistry; Protein Synthesis Inhibitors/pharmacology; RNA, Fungal/genetics; RNA, Ribosomal/genetics; Ribosomes/genetics; Ribosomes/metabolism; Saccharomyces cerevisiae/drug effects; Saccharomyces cerevisiae/genetics; Saccharomyces cerevisiae/metabolism; Saccharomyces cerevisiae Proteins/biosynthesis; Structure-Activity Relationship

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ribosomes / Macrolides / Anti-Bacterial Agents Limits: Humans Language: En Journal: Nat Commun Year: 2021 Document type: Article

Fulltext

XML

PubMed Links

Search on Google