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Incorporation of a Novel CD16-Specific Single-Domain Antibody into Multispecific Natural Killer Cell Engagers With Potent ADCC.
van Faassen, Henk; Jo, Dong-Hyeon; Ryan, Shannon; Lowden, Michael J; Raphael, Shalini; MacKenzie, C Roger; Lee, Seung-Hwan; Hussack, Greg; Henry, Kevin A.
Affiliation
  • van Faassen H; Human Health Therapeutics Research Centre, Life Sciences Division, National Research Council Canada, 100 Sussex Drive, Ottawa, Ontario K1A 0R6, Canada.
  • Jo DH; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, Ontario K1H 8M5, Canada.
  • Ryan S; Human Health Therapeutics Research Centre, Life Sciences Division, National Research Council Canada, 100 Sussex Drive, Ottawa, Ontario K1A 0R6, Canada.
  • Lowden MJ; Human Health Therapeutics Research Centre, Life Sciences Division, National Research Council Canada, 100 Sussex Drive, Ottawa, Ontario K1A 0R6, Canada.
  • Raphael S; Human Health Therapeutics Research Centre, Life Sciences Division, National Research Council Canada, 100 Sussex Drive, Ottawa, Ontario K1A 0R6, Canada.
  • MacKenzie CR; Human Health Therapeutics Research Centre, Life Sciences Division, National Research Council Canada, 100 Sussex Drive, Ottawa, Ontario K1A 0R6, Canada.
  • Lee SH; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, Ontario K1H 8M5, Canada.
  • Hussack G; Human Health Therapeutics Research Centre, Life Sciences Division, National Research Council Canada, 100 Sussex Drive, Ottawa, Ontario K1A 0R6, Canada.
  • Henry KA; Human Health Therapeutics Research Centre, Life Sciences Division, National Research Council Canada, 100 Sussex Drive, Ottawa, Ontario K1A 0R6, Canada.
Mol Pharm ; 18(6): 2375-2384, 2021 06 07.
Article in En | MEDLINE | ID: mdl-33999642
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Recombinant Fusion Proteins / Killer Cells, Natural / Antibodies, Bispecific / Single-Domain Antibodies / Neoplasms Limits: Animals / Humans Language: En Journal: Mol Pharm Year: 2021 Document type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Recombinant Fusion Proteins / Killer Cells, Natural / Antibodies, Bispecific / Single-Domain Antibodies / Neoplasms Limits: Animals / Humans Language: En Journal: Mol Pharm Year: 2021 Document type: Article