Cdk5 regulatory subunit-associated protein 1 knockout mice show hearing loss phenotypically similar to age-related hearing loss.

Miwa, Toru; Wei, Fan-Yan; Tomizawa, Kazuhito

Miwa, Toru; Wei, Fan-Yan; Tomizawa, Kazuhito.

Affiliation

Miwa T; Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 6068507, Japan. t-miwa@kitano-hp.or.jp.
Wei FY; Department of Otolaryngology-Head and Neck Surgery, Kitano Hospital, Tazuke Kofukai Medical Research Institute, 2-4-20 Ougimaci, Kita-ku, Osaka, 5308480, Japan. t-miwa@kitano-hp.or.jp.
Tomizawa K; Department of Molecular Physiology, Faculty of Life Sciences, Kumamoto University, 1-1-1- Honjo, Chuo-ku, Kumamoto, 8608556, Japan.

Mol Brain ; 14(1): 82, 2021 05 17.

Article in En | MEDLINE | ID: mdl-34001214

Subject(s)

Aging/pathology; Cell Cycle Proteins/deficiency; Mitochondrial Proteins/genetics; Presbycusis/genetics; Sulfur Group Transferases/genetics; Action Potentials; Animals; Apoptosis; Cell Cycle Proteins/metabolism; Female; Fibroblasts/metabolism; Hair Cells, Auditory/metabolism; Metabolome; Mice, Inbred C57BL; Mice, Knockout; Mitochondria/metabolism; Mitochondria/ultrastructure; Phenotype; Reactive Oxygen Species/metabolism; Spiral Ganglion/metabolism; Spiral Ligament of Cochlea/metabolism; Stress, Physiological; Stria Vascularis/metabolism

Key words

Auditory brainstem responses; Cdk5rap1; Endocochlear potentials; Hearing loss; Mitochondrial tRNA; Spiral ligament of cochlea

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Full text: 1 Collection: 01-internacional Health context: 6_ODS3_enfermedades_notrasmisibles Database: MEDLINE Main subject: Presbycusis / Aging / Cell Cycle Proteins / Sulfur Group Transferases / Mitochondrial Proteins Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals Language: En Journal: Mol Brain Year: 2021 Document type: Article

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