How hydrophilic group affects drug-protein binding modes: Differences in interaction between sirtuins inhibitors Tenovin-1/Tenovin-6 and human serum albumin.

Gan, Na; Sun, Qiaomei; Suo, Zili; Zhang, Shuangshuang; Zhao, Ludan; Xiang, Hongzhao; Wang, Wenjing; Li, Zhiqiang; Liao, Xiaoxiang; Li, Hui

Gan, Na; Sun, Qiaomei; Suo, Zili; Zhang, Shuangshuang; Zhao, Ludan; Xiang, Hongzhao; Wang, Wenjing; Li, Zhiqiang; Liao, Xiaoxiang; Li, Hui.

Affiliation

Gan N; School of Chemical Engineering, Sichuan University, Chengdu, 610065, Sichuan, China.
Sun Q; School of Chemical Engineering, Sichuan University, Chengdu, 610065, Sichuan, China. Electronic address: qiaomeisun@163.com.
Suo Z; School of Chemical Engineering, Sichuan University, Chengdu, 610065, Sichuan, China.
Zhang S; School of Chemical Engineering, Sichuan University, Chengdu, 610065, Sichuan, China.
Zhao L; School of Chemical Engineering, Sichuan University, Chengdu, 610065, Sichuan, China.
Xiang H; School of Chemical Engineering, Sichuan University, Chengdu, 610065, Sichuan, China.
Wang W; School of Chemical Engineering, Sichuan University, Chengdu, 610065, Sichuan, China.
Li Z; R&D Center, China Tobacco Yunnan Industrial Co., Ltd., No. 367, Hongjin Road, Kunming, 650000, China.
Liao X; R&D Center, China Tobacco Yunnan Industrial Co., Ltd., No. 367, Hongjin Road, Kunming, 650000, China.
Li H; School of Chemical Engineering, Sichuan University, Chengdu, 610065, Sichuan, China. Electronic address: lihuilab@sina.com.

J Pharm Biomed Anal ; 201: 114121, 2021 Jul 15.

Article in En | MEDLINE | ID: mdl-34020341

Subject(s)

Pharmaceutical Preparations; Sirtuins; Acetanilides; Benzamides; Binding Sites; Circular Dichroism; Humans; Hydrophobic and Hydrophilic Interactions; Molecular Docking Simulation; Protein Binding; Serum Albumin, Human/metabolism; Spectrometry, Fluorescence; Thermodynamics; Thiourea/analogs & derivatives

Key words

Human serum albumin; Interaction; Sirtuin inhibitor

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pharmaceutical Preparations / Sirtuins Limits: Humans Language: En Journal: J Pharm Biomed Anal Year: 2021 Document type: Article

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