Cell size homeostasis is maintained by CDK4-dependent activation of p38 MAPK.
Dev Cell
; 56(12): 1756-1769.e7, 2021 06 21.
Article
in En
| MEDLINE
| ID: mdl-34022133
ABSTRACT
While molecules that promote the growth of animal cells have been identified, it remains unclear how such signals are orchestrated to determine a characteristic target size for different cell types. It is increasingly clear that cell size is determined by size checkpoints-mechanisms that restrict the cell cycle progression of cells that are smaller than their target size. Previously, we described a p38 MAPK-dependent cell size checkpoint mechanism whereby p38 is selectively activated and prevents cell cycle progression in cells that are smaller than a given target size. In this study, we show that the specific target size required for inactivation of p38 and transition through the cell cycle is determined by CDK4 activity. Our data suggest a model whereby p38 and CDK4 cooperate analogously to the function of a thermostat while p38 senses irregularities in size, CDK4 corresponds to the thermostat dial that sets the target size.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cell Cycle
/
P38 Mitogen-Activated Protein Kinases
/
Cell Size
/
Cyclin-Dependent Kinase 4
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Dev Cell
Year:
2021
Document type:
Article