Latent CMV Infection Is Associated With Lower Influenza Virus-Specific Memory T-Cell Frequencies, but Not With an Impaired T-Cell Response to Acute Influenza Virus Infection.

van den Berg, Sara P H; Lanfermeijer, Josien; Jacobi, Ronald H J; Hendriks, Marion; Vos, Martijn; van Schuijlenburg, Roos; Nanlohy, Nening M; Borghans, José A M; van Beek, Josine; van Baarle, Debbie; de Wit, Jelle

van den Berg, Sara P H; Lanfermeijer, Josien; Jacobi, Ronald H J; Hendriks, Marion; Vos, Martijn; van Schuijlenburg, Roos; Nanlohy, Nening M; Borghans, José A M; van Beek, Josine; van Baarle, Debbie; de Wit, Jelle.

Affiliation

van den Berg SPH; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, Netherlands.
Lanfermeijer J; Center for Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands.
Jacobi RHJ; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, Netherlands.
Hendriks M; Center for Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands.
Vos M; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, Netherlands.
van Schuijlenburg R; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, Netherlands.
Nanlohy NM; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, Netherlands.
Borghans JAM; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, Netherlands.
van Beek J; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, Netherlands.
van Baarle D; Center for Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands.
de Wit J; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, Netherlands.

Front Immunol ; 12: 663664, 2021.

Article in En | MEDLINE | ID: mdl-34025665

Subject(s)

Cytomegalovirus Infections/immunology; Cytomegalovirus Infections/virology; Cytomegalovirus/physiology; Immunologic Memory; Influenza A virus/immunology; Influenza, Human/immunology; T-Lymphocytes/immunology; Virus Latency/immunology; Adult; Aged; Aged, 80 and over; Cellular Senescence/immunology; Coinfection; Cytokines/blood; Cytokines/metabolism; Cytomegalovirus Infections/metabolism; Female; Humans; Influenza, Human/diagnosis; Influenza, Human/virology; Male; Middle Aged; Severity of Illness Index; T-Cell Antigen Receptor Specificity; T-Lymphocytes/metabolism; Young Adult

Key words

T cell; ageing; cytomegalovirus infection; immune response; influenza infection

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Full text: 1 Collection: 01-internacional Health context: 2_ODS3 Database: MEDLINE Main subject: Influenza A virus / T-Lymphocytes / Virus Latency / Cytomegalovirus Infections / Cytomegalovirus / Influenza, Human / Immunologic Memory Type of study: Diagnostic_studies / Risk_factors_studies Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Front Immunol Year: 2021 Document type: Article

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