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Extensive pleiotropism and allelic heterogeneity mediate metabolic effects of IRX3 and IRX5.
Sobreira, Débora R; Joslin, Amelia C; Zhang, Qi; Williamson, Iain; Hansen, Grace T; Farris, Kathryn M; Sakabe, Noboru J; Sinnott-Armstrong, Nasa; Bozek, Grazyna; Jensen-Cody, Sharon O; Flippo, Kyle H; Ober, Carole; Bickmore, Wendy A; Potthoff, Matthew; Chen, Mengjie; Claussnitzer, Melina; Aneas, Ivy; Nóbrega, Marcelo A.
Affiliation
  • Sobreira DR; Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA. deborarsobreira@gmail.com ianeas@bsd.uchicago.edu nobrega@uchicago.edu.
  • Joslin AC; Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.
  • Zhang Q; Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.
  • Williamson I; Section of Genetic Medicine, Department of Medicine, University of Chicago, Chicago, IL 60637, USA.
  • Hansen GT; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.
  • Farris KM; Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.
  • Sakabe NJ; Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.
  • Sinnott-Armstrong N; Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.
  • Bozek G; Department of Genetics, Stanford University, Stanford 94305 CA, USA.
  • Jensen-Cody SO; Metabolism Program and Cardiovascular Disease Initiative, Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA.
  • Flippo KH; Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.
  • Ober C; Department of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.
  • Bickmore WA; Department of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.
  • Potthoff M; Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.
  • Chen M; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.
  • Claussnitzer M; Department of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.
  • Aneas I; Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.
  • Nóbrega MA; Section of Genetic Medicine, Department of Medicine, University of Chicago, Chicago, IL 60637, USA.
Science ; 372(6546): 1085-1091, 2021 06 04.
Article in En | MEDLINE | ID: mdl-34083488
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / Brain / Adipose Tissue / Homeodomain Proteins / Obesity Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Science Year: 2021 Document type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / Brain / Adipose Tissue / Homeodomain Proteins / Obesity Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Science Year: 2021 Document type: Article