Optimization of physicochemical properties of pyridone-based EP3 receptor antagonists.
Bioorg Med Chem Lett
; 47: 128172, 2021 09 01.
Article
in En
| MEDLINE
| ID: mdl-34091043
A novel series of pyridone-based EP3 receptor antagonists was optimized for good physical properties and oral bioavailability in rodents. The lead compounds 3h, 3l and 4d displayed good in vitro profiles, moderate to good metabolic stability and good rodent PK profiles with low clearance, high oral exposure and acceptable half-life.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pyridones
/
Receptors, Prostaglandin E, EP3 Subtype
Limits:
Humans
Language:
En
Journal:
Bioorg Med Chem Lett
Year:
2021
Document type:
Article