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Baihui (DU20)-penetrating-Qubin (GB7) acupuncture regulates microglia polarization through miR-34a-5p/Klf4 signaling in intracerebral hemorrhage rats.
Li, Dan; Zhao, Yonghou; Bai, Peng; Li, Yan; Wan, Siqi; Zhu, Xi; Liu, Mengyu.
Affiliation
  • Li D; Department of Acupuncture, Beijing University of Chinese Medicine Third Affiliated Hospital, No. 51 Xiaoguan Street, Anwai, Chaoyang District, Beijing 100029, P.R. China.
  • Zhao Y; Department of Psychiatry, Heilongjiang Mental Hospital, No. 153 Hengdao Street, Xiangfang District, Harbin 150036, P.R. China.
  • Bai P; Department of Acupuncture, Beijing University of Chinese Medicine Third Affiliated Hospital, No. 51 Xiaoguan Street, Anwai, Chaoyang District, Beijing 100029, P.R. China.
  • Li Y; Department of Otolaryngology, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, No. 26 Heping Road, Xiangfang District, Harbin 150040, P.R. China.
  • Wan S; School of Traditionnal Chinese Internal Medicine, Dongzhimen Hosptial, Beijing University of Chinese Medicine, No. 5 Haiyuncang, Dongcheng District, Beijing 100700, P.R. China.
  • Zhu X; School of Acupuncture and Massage, Beijing University of Chinese Medicine, No. 11 North Three-ring East Road, Chaoyang District, Beijing 100029, P.R. China.
  • Liu M; Department of Acupuncture, Beijing University of Chinese Medicine Third Affiliated Hospital, No. 51 Xiaoguan Street, Anwai, Chaoyang District, Beijing 100029, P.R. China.
Exp Anim ; 70(4): 469-478, 2021 Nov 10.
Article in En | MEDLINE | ID: mdl-34108361
ABSTRACT
Intracerebral hemorrhage (ICH) is the most devastating subtype of stroke with high morbidity and mortality. The previous study has confirmed the therapeutic effect of Baihui (DU20)-penetrating-Qubin (GB7) acupuncture on ICH, while the related mechanism is left to be revealed. The aim of this study was to investigate the relevant mechanisms. ICH rat models were established utilizing the autologous blood injection method and the beneficial effect was found after DU20-penetrating-GB7 acupuncture along with decreased miR-34a-5p levels in the perihemorrhagic penumbra. Inversely, upregulating miR-34a-5p expression inhibited microglia M2 polarization while accelerated M1 polarization through targeting Krüppel-like factor 4 (Klf4), and thereby diminished the protective effect of DU20-penetrating-GB7 acupuncture on ICH. The results suggested the therapeutic effect of DU20-penetrating-GB7 acupuncture on ICH might be attributed to its modulation on microglia polarization through miR-34a-5p/Klf4 signaling.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Acupuncture Therapy / Cerebral Hemorrhage / Cell Polarity / Microglia / MicroRNAs / Kruppel-Like Transcription Factors Type of study: Prognostic_studies Limits: Animals Language: En Journal: Exp Anim Year: 2021 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Acupuncture Therapy / Cerebral Hemorrhage / Cell Polarity / Microglia / MicroRNAs / Kruppel-Like Transcription Factors Type of study: Prognostic_studies Limits: Animals Language: En Journal: Exp Anim Year: 2021 Document type: Article