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Health-related quality of life and associated factors in HIV-positive transplant candidates and recipients from a HIV-positive donor.
Martin, Claire Juliet; Muller, Elmi; Labadarios, Demetre; Veldman, Frederick Johannes; Kassier, Susanna Maria.
Affiliation
  • Martin CJ; University of Pretoria, Pretoria, Gauteng, South Africa. claire.martin@up.ac.za.
  • Muller E; University of KwaZulu-Natal, Pietermaritzburg, KwaZulu-Natal, South Africa. claire.martin@up.ac.za.
  • Labadarios D; Department of Surgery, University of Cape Town, Cape Town, Western Cape, South Africa.
  • Veldman FJ; Department of Human Nutrition, Stellenbosch University, Stellenbosch, Western Cape, South Africa.
  • Kassier SM; Sefako Makgatho Health Sciences University, Pretoria, Gauteng, South Africa.
Qual Life Res ; 31(1): 171-184, 2022 Jan.
Article in En | MEDLINE | ID: mdl-34156597
INTRODUCTION: HRQOL in transplant candidates and recipients who are also infected with HIV and are awaiting a kidney, or have received one from a HIV-positive donor, has not been previously investigated. METHODS: The HRQOL of 47 HIV-positive kidney transplant candidates and 21 recipients from HIV-positive donors was evaluated using the Short Form-36 (SF-36) and face to face interviews at baseline and at 6 months. The correlation between SF-36 scores and sociodemographic, clinical and nutritional factors was determined. RESULTS: 68 patients completed the SF-36 at baseline and 6 months. Transplant candidates: transplant candidates had lower HRQOL than recipients. The main mental stressors were income, employment and waiting for a donor. Physical health complaints were body pain (BP) and fatigue. Pre-albumin and BMI was positively correlated with general health at baseline (r = 0.401, p = 0.031 and r = 0.338, p = 0.025). Besides a positive association with role physical (RP) and BP, albumin was associated with overall physical composite score (PCS) (r = 0.329, p = 0.024) at 6 months. Transplant recipients: Transplant recipients had high HRQOL scores in all domains. PCS was 53.8 ± 10.0 and 56.6 ± 6.5 at baseline and 6 months respectively. MCS was 51.3 ± 11.5 and 54.2 ± 8.5 at baseline and 6 months respectively. Albumin correlated positively with PCS (r = 0.464, p = 0.034) at 6 months and role emotional (RE) (r = 0.492, p = 0.024). Higher pre-albumin was associated with better RE and RP abilities and MCS (r = 0.495, p = 0.034). MAMC was associated with four domains of physical health and strongly correlated with PCS (r = 0.821, p = 0.000). CONCLUSION: Strategies to improve HRQOL include ongoing social support, assistance with employment issues and optimising nutritional status.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: HIV Infections / Kidney Transplantation Type of study: Observational_studies / Qualitative_research / Risk_factors_studies Aspects: Patient_preference Limits: Humans Language: En Journal: Qual Life Res Year: 2022 Document type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: HIV Infections / Kidney Transplantation Type of study: Observational_studies / Qualitative_research / Risk_factors_studies Aspects: Patient_preference Limits: Humans Language: En Journal: Qual Life Res Year: 2022 Document type: Article