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Transmembrane Protease TMPRSS4 Promotes the Formation and Development of Mismatch Repair Deficient Colon Cancer Liver Metastasis.
Yang, Y S; Wen, D; Zhao, X F.
Affiliation
  • Yang YS; Department of General Surgery, Dalian University Affiliated Xinhua Hospital, Dalian, China.
  • Wen D; Department of General Surgery, Dalian University Affiliated Xinhua Hospital, Dalian, China.
  • Zhao XF; Department of General Surgery, Dalian University Affiliated Xinhua Hospital, Dalian, China. zoserbong@163.com.
Bull Exp Biol Med ; 171(2): 242-246, 2021 May.
Article in En | MEDLINE | ID: mdl-34173918
ABSTRACT
We studied metastasis-promoting effect of transmembrane protease TMPRSS4 on mismatch repair (MMR)-deficient colorectal cancer liver metastasis in BALB/c nude mouse model. Histomorphological and histopathological studies showed that the number of liver metastases in the study group were significantly higher than that in the control group (p<0.05). The expression of TMPRSS4 mRNA and protein in the study group were obviously higher than in the control group (p<0.05). These findings suggest that TMPRSS4 possesses a metastasis-promoting effect and its low expression can effectively block the progression of MMR-deficient colon cancer liver metastasis.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Serine Endopeptidases / Colonic Neoplasms / Liver Neoplasms / Membrane Proteins Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Bull Exp Biol Med Year: 2021 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Serine Endopeptidases / Colonic Neoplasms / Liver Neoplasms / Membrane Proteins Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Bull Exp Biol Med Year: 2021 Document type: Article