Potential protective role of astrocytes in the pathogenesis of astrocyte-mediated synaptic plasticity of Parkinson's disease.
J Integr Neurosci
; 20(2): 515-525, 2021 Jun 30.
Article
in En
| MEDLINE
| ID: mdl-34258954
ABSTRACT
Astrocytes are the most abundant glia in the central nervous system that play a significant role in disease. Recently, it roles of synaptic plasticity in neuropathological damages have been questioned whether the structural and functional plasticity of synapses contributes to the pathogenesis of Parkinson's disease. The regulation of synaptic plasticity by astrocytes has also been widely researched based on astrocytes regulate synaptic plasticity by releasing Adenosine triphosphate, glutamate, and D-serine. We discuss the possible role of astrocytes in the regulation of synaptic plasticity, which may provide a new direction to Parkinson's disease treatment.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Parkinson Disease
/
Astrocytes
/
Neuronal Plasticity
Type of study:
Etiology_studies
Limits:
Humans
Language:
En
Journal:
J Integr Neurosci
Year:
2021
Document type:
Article