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Independent risk factors of hypoxemia in patients after surgery with acute type A aortic dissection.
Zhou, Jing; Pan, Jieyi; Yu, Yuheng; Huang, Weixiang; Lai, Yan; Liang, Weibo; Nong, Lingbo; Liu, Xuesong; Chen, Sibei; Xu, Yonghao; He, Weiqun; Xu, Yuanda; Liu, Xiaoqing; Li, Yimin; Huang, Yongbo; Sang, Ling.
Affiliation
  • Zhou J; Department of Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Guangzhou Institute of Respiratory Health, Guangzhou, China; State Key Laboratory of Respiratory Disease, Guangzhou, China.
  • Pan J; Department of Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Guangzhou Institute of Respiratory Health, Guangzhou, China; State Key Laboratory of Respiratory Disease, Guangzhou, China.
  • Yu Y; Department of Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Guangzhou Institute of Respiratory Health, Guangzhou, China; State Key Laboratory of Respiratory Disease, Guangzhou, China.
  • Huang W; Department of Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Guangzhou Institute of Respiratory Health, Guangzhou, China; State Key Laboratory of Respiratory Disease, Guangzhou, China.
  • Lai Y; Department of Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Guangzhou Institute of Respiratory Health, Guangzhou, China; State Key Laboratory of Respiratory Disease, Guangzhou, China.
  • Liang W; Department of Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Guangzhou Institute of Respiratory Health, Guangzhou, China; State Key Laboratory of Respiratory Disease, Guangzhou, China.
  • Nong L; Department of Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Guangzhou Institute of Respiratory Health, Guangzhou, China; State Key Laboratory of Respiratory Disease, Guangzhou, China.
  • Liu X; Department of Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Guangzhou Institute of Respiratory Health, Guangzhou, China; State Key Laboratory of Respiratory Disease, Guangzhou, China.
  • Chen S; Department of Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Guangzhou Institute of Respiratory Health, Guangzhou, China; State Key Laboratory of Respiratory Disease, Guangzhou, China.
  • Xu Y; Department of Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Guangzhou Institute of Respiratory Health, Guangzhou, China; State Key Laboratory of Respiratory Disease, Guangzhou, China.
  • He W; Department of Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Guangzhou Institute of Respiratory Health, Guangzhou, China; State Key Laboratory of Respiratory Disease, Guangzhou, China.
  • Xu Y; Department of Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Guangzhou Institute of Respiratory Health, Guangzhou, China; State Key Laboratory of Respiratory Disease, Guangzhou, China.
  • Liu X; Department of Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Guangzhou Institute of Respiratory Health, Guangzhou, China; State Key Laboratory of Respiratory Disease, Guangzhou, China.
  • Li Y; Department of Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Guangzhou Institute of Respiratory Health, Guangzhou, China; State Key Laboratory of Respiratory Disease, Guangzhou, China.
  • Huang Y; Department of Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Guangzhou Institute of Respiratory Health, Guangzhou, China; State Key Laboratory of Respiratory Disease, Guangzhou, China.
  • Sang L; Department of Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Guangzhou Institute of Respiratory Health, Guangzhou, China; State Key Laboratory of Respiratory Disease, Guangzhou, China; Guangzhou Laboratory, Guangzhou, China.
Ann Palliat Med ; 10(7): 7388-7397, 2021 Jul.
Article in En | MEDLINE | ID: mdl-34263634
ABSTRACT

BACKGROUND:

This study aimed to investigate independent risk factors of postoperative hypoxemia in patients with acute type A aortic dissection (ATAAD).

METHODS:

A single-center retrospective study was conducted with enrolled 75 ATAAD patients following surgery, which were stratified into three groups on the basis of the postoperative PaO2/FiO2 ratio severe hypoxemia group (PaO2/FiO2 ratio ≤100 mmHg); moderate hypoxemia group (100 mmHg < PaO2/FiO2 ratio ≤200 mmHg); and non-hypoxemia group (PaO2/FiO2 ratio >200 mmHg). The patient's demography, perioperative laboratory results, operative details, clinical outcomes were collected and analyzed. Univariable and multivariable analyses were performed and logistic regression model was established.

RESULTS:

The incidence of postoperative severe hypoxemia and hypoxemia was 32% and 52%, respectively. Among the three groups, severe hypoxemia group exhibited a high significance of body mass index (BMI) and preoperative white blood cell (WBC) and main distribution of hypertension; meanwhile, Marfan syndrome was mainly distributed in non-hypoxemia group. On intensive care unit (ICU) admission, severe hypoxemia group exhibited a high significance of Acute Physiology and Chronic Health Evaluation (APACHE II) score of postoperative patients, and more patients would present shock. Moreover, severe hypoxemia group patients had a higher incidence of postoperative acute kidney injury (AKI) and usage of renal replacement therapy, longer length of stay (LOS) of ICU, and shorter 28 days ventilator-free days (VFDs).

CONCLUSIONS:

The incidence of postoperative hypoxemia was high in ATAAD patients owing to comprehensive high-risk factors. Besides, postoperative complications negatively impacted their clinical outcomes.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aortic Dissection Type of study: Etiology_studies / Observational_studies / Prognostic_studies Limits: Humans Language: En Journal: Ann Palliat Med Year: 2021 Document type: Article
Fulltext
Print
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aortic Dissection Type of study: Etiology_studies / Observational_studies / Prognostic_studies Limits: Humans Language: En Journal: Ann Palliat Med Year: 2021 Document type: Article