Covalent and Noncovalent Targeting of the Tcf4/ß-Catenin Strand Interface with ß-Hairpin Mimics.
ACS Chem Biol
; 16(8): 1518-1525, 2021 08 20.
Article
in En
| MEDLINE
| ID: mdl-34286954
ABSTRACT
ß-Strands are a fundamental component of protein structure, and these extended peptide regions serve as binding epitopes for numerous protein-protein complexes. However, synthetic mimics that capture the conformation of these epitopes and inhibit selected protein-protein interactions are rare. Here we describe covalent and noncovalent ß-hairpin mimics of an extended strand region mediating the Tcf4/ß-catenin interaction. Our efforts afford a rationally designed lead for an underexplored region of ß-catenin, which has been the subject of numerous ligand discovery campaigns.
Full text:
1
Collection:
01-internacional
Health context:
3_ND
Database:
MEDLINE
Main subject:
Peptides, Cyclic
/
Protein Binding
/
Beta Catenin
/
Transcription Factor 4
Language:
En
Journal:
ACS Chem Biol
Year:
2021
Document type:
Article