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BACE inhibitor treatment of mice induces hyperactivity in a Seizure-related gene 6 family dependent manner without altering learning and memory.
Nash, A; Gijsen, H J M; Hrupka, B J; Teng, K S-L; Lichtenthaler, S F; Takeshima, H; Gunnersen, J M; Munro, K M.
Affiliation
  • Nash A; Department of Anatomy and Physiology, University of Melbourne, Melbourne, VIC, Australia.
  • Gijsen HJM; Discovery Sciences, Janssen Research & Development, Beerse, Belgium.
  • Hrupka BJ; Department of Neuroscience, Janssen Research & Development, Beerse, Belgium.
  • Teng KS; Department of Anatomy and Physiology, University of Melbourne, Melbourne, VIC, Australia.
  • Lichtenthaler SF; German Centre for Neurodegenerative Diseases (DZNE), Munich, Germany.
  • Takeshima H; Neuroproteomics, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, 81675, Munich, Germany.
  • Gunnersen JM; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
  • Munro KM; Division of Pharmaceutical Sciences, Graduate School and Faculty of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.
Sci Rep ; 11(1): 15084, 2021 07 23.
Article in En | MEDLINE | ID: mdl-34302009
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Seizures / Aspartic Acid Endopeptidases / Amyloid Precursor Protein Secretases / Learning / Memory / Nerve Tissue Proteins Type of study: Prognostic_studies Limits: Animals Language: En Journal: Sci Rep Year: 2021 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Seizures / Aspartic Acid Endopeptidases / Amyloid Precursor Protein Secretases / Learning / Memory / Nerve Tissue Proteins Type of study: Prognostic_studies Limits: Animals Language: En Journal: Sci Rep Year: 2021 Document type: Article