Mycobacterial diseases in patients with inborn errors of immunity.
Curr Opin Immunol
; 72: 262-271, 2021 10.
Article
in En
| MEDLINE
| ID: mdl-34315005
ABSTRACT
Clinical disease caused by the agent of tuberculosis, Mycobacterium tuberculosis, and by less virulent mycobacteria, such as bacillus Calmette-Guérin (BCG) vaccines and environmental mycobacteria, can result from inborn errors of immunity (IEIs). IEIs underlie more than 450 conditions, each associated with an impairment of the development and/or function of hematopoietic and/or non-hematopoietic cells involved in host defense. Only a minority of IEIs confer predisposition to mycobacterial disease. The IEIs underlying susceptibility to bona fide tuberculosis are less well delineated than those responsible for susceptibility to less virulent mycobacteria. However, all these IEIs share a defining feature the impairment of immunity mediated by interferon gamma (IFN-γ). More profound IFN-γ deficiency is associated with a greater vulnerability to weakly virulent mycobacteria, whereas more selective IFN-γ deficiency is associated with a more selective predisposition to mycobacterial disease. We review here recent progress in the study of IEIs underlying mycobacterial diseases.
Full text:
1
Collection:
01-internacional
Health context:
3_ND
Database:
MEDLINE
Main subject:
Genetic Variation
/
Genetic Predisposition to Disease
/
Immunity
/
Mycobacterium
/
Mycobacterium Infections
Type of study:
Diagnostic_studies
Limits:
Humans
Language:
En
Journal:
Curr Opin Immunol
Year:
2021
Document type:
Article