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PCNA inhibition enhances the cytotoxicity of ß-lapachone in NQO1-Positive cancer cells by augmentation of oxidative stress-induced DNA damage.
Su, Xiaolin; Wang, Jiangwei; Jiang, Lingxiang; Chen, Yaomin; Lu, Tao; Mendonca, Marc S; Huang, Xiumei.
Affiliation
  • Su X; Department of Biochemistry and Molecular Biology, Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
  • Wang J; Department of Radiation Oncology, Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
  • Jiang L; Department of Radiation Oncology, Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
  • Chen Y; Indiana University Health Pathology Laboratory, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
  • Lu T; Department of Pharmacology and Toxicology, Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
  • Mendonca MS; Department of Radiation Oncology, Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
  • Huang X; Department of Radiation Oncology, Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, IN, 46202, USA. Electronic address: xiuhuang@iu.edu.
Cancer Lett ; 519: 304-314, 2021 10 28.
Article in En | MEDLINE | ID: mdl-34329742
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA Damage / Naphthoquinones / NAD(P)H Dehydrogenase (Quinone) / Proliferating Cell Nuclear Antigen / Oxidative Stress / Neoplasms / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Cancer Lett Year: 2021 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA Damage / Naphthoquinones / NAD(P)H Dehydrogenase (Quinone) / Proliferating Cell Nuclear Antigen / Oxidative Stress / Neoplasms / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Cancer Lett Year: 2021 Document type: Article