Differential biological effects of aromatase inhibitors: Apoptosis, autophagy, senescence and modulation of the hormonal status in breast cancer cells.

Augusto, Tiago V; Amaral, Cristina; Almeida, Cristina F; Teixeira, Natércia; Correia-da-Silva, Georgina

Augusto, Tiago V; Amaral, Cristina; Almeida, Cristina F; Teixeira, Natércia; Correia-da-Silva, Georgina.

Affiliation

Augusto TV; UCIBIO.REQUIMTE, Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira N° 228, 4050-313, Porto, Portugal.
Amaral C; UCIBIO.REQUIMTE, Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira N° 228, 4050-313, Porto, Portugal.
Almeida CF; UCIBIO.REQUIMTE, Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira N° 228, 4050-313, Porto, Portugal.
Teixeira N; UCIBIO.REQUIMTE, Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira N° 228, 4050-313, Porto, Portugal. Electronic address: natercia@ff.up.pt.
Correia-da-Silva G; UCIBIO.REQUIMTE, Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira N° 228, 4050-313, Porto, Portugal. Electronic address: george@ff.up.pt.

Mol Cell Endocrinol ; 537: 111426, 2021 11 01.

Article in En | MEDLINE | ID: mdl-34391846

Subject(s)

Apoptosis; Aromatase Inhibitors/pharmacology; Autophagy; Breast Neoplasms/pathology; Cellular Senescence; Hormones/metabolism; Anastrozole/pharmacology; Androstadienes/pharmacology; Biomarkers/metabolism; Cell Cycle/drug effects; Cell Line, Tumor; Cell Proliferation/drug effects; Cell Survival/drug effects; Cellular Senescence/drug effects; Cyclins/metabolism; Early Growth Response Protein 3/genetics; Early Growth Response Protein 3/metabolism; Estrogens/metabolism; Female; Gene Expression Regulation, Neoplastic/drug effects; Humans; Letrozole/pharmacology; Receptors, Androgen/metabolism; Receptors, Estrogen/antagonists & inhibitors; Receptors, Estrogen/metabolism; Signal Transduction/drug effects; Tumor Suppressor Proteins/genetics; Tumor Suppressor Proteins/metabolism

Key words

Androgen receptor; Aromatase inhibitors; Autophagy; Breast cancer; Estrogen receptor; Senescence

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Health context: 6_ODS3_enfermedades_notrasmisibles Database: MEDLINE Main subject: Autophagy / Breast Neoplasms / Cellular Senescence / Apoptosis / Aromatase Inhibitors / Hormones Limits: Female / Humans Language: En Journal: Mol Cell Endocrinol Year: 2021 Document type: Article

Fulltext

XML

PubMed Links

Search on Google