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Structural optimization, synthesis and in vitro synergistic anticancer activities of combinations of new N3-substituted dihydropyrimidine calcium channel blockers with cisplatin and etoposide.
El-Wakil, Marwa H; Teleb, Mohamed; Abu-Serie, Marwa M; Huang, Sun; Zamponi, Gerald W; Fahmy, Hesham.
Affiliation
  • El-Wakil MH; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt.
  • Teleb M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt. Electronic address: mohamed.t.ismail@alexu.edu.eg.
  • Abu-Serie MM; Department of Medical Biotechnology, Genetic Engineering and Biotechnology Research Institute, City of Scientific Research and Technological Applications (SRTA-City), Egypt.
  • Huang S; Department of Physiology & Pharmacology, Hotchkiss Brain Institute, Alberta Children's Hospital Research Institute, University of Calgary, 3330 Hospital Drive NW, Calgary T2N 4N1, Canada.
  • Zamponi GW; Department of Physiology & Pharmacology, Hotchkiss Brain Institute, Alberta Children's Hospital Research Institute, University of Calgary, 3330 Hospital Drive NW, Calgary T2N 4N1, Canada.
  • Fahmy H; Department of Pharmaceutical Sciences, College of Pharmacy & Allied Health Sciences, South Dakota State University, Brookings, SD 57006, USA. Electronic address: Hesham.Fahmy@sdstate.edu.
Bioorg Chem ; 115: 105262, 2021 10.
Article in En | MEDLINE | ID: mdl-34411980
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Calcium Channel Blockers / Cisplatin / Calcium Channels, T-Type / Etoposide / Antineoplastic Agents Limits: Humans Language: En Journal: Bioorg Chem Year: 2021 Document type: Article
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Calcium Channel Blockers / Cisplatin / Calcium Channels, T-Type / Etoposide / Antineoplastic Agents Limits: Humans Language: En Journal: Bioorg Chem Year: 2021 Document type: Article