Pilot study of fractional microneedling radiofrequency for hidradenitis suppurativa assessed by clinical response and histology.
Clin Exp Dermatol
; 47(2): 335-342, 2022 Feb.
Article
in En
| MEDLINE
| ID: mdl-34431555
ABSTRACT
BACKGROUND:
Hidradenitis suppurativa (HS) is a devastating chronic inflammatory skin disease with frequent recurrences. Various systemic treatments and procedures have been used but the efficacy of fractional microneedling radiofrequency (FMR) has not been reported.AIM:
To evaluate the clinical and histological efficacy of FMR in the treatment of HS lesions.METHODS:
An 8-week, prospective, split-body, unblinded study was conducted, which enrolled 10 adult patients with mild to moderate HS to receive 3 sessions of FMR treatment biweekly. HS severity was assessed using the number and type of lesions, HS Physician Global Assessment (HS-PGA) and the modified Sartorius score (mSS). Skin biopsies were performed on participants to assess change in inflammation before and after FMR.RESULTS:
Severity of HS was significantly reduced on the FMR-treated side of the body, but not on the control side. Inflammatory HS lesions were significantly reduced after 4 weeks, while HS-PGA and mSS were significantly decreased after 6 weeks. Immunohistochemistry staining showed decreased expression of inflammatory markers including neutrophil elastases, interleukin (IL)-8 and IL-17, tumour necrosis factor-α, transforming growth factor-ß1 and matrix metalloproteinases.CONCLUSION:
FMR may be a viable treatment option for mild to moderate HS.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Hidradenitis Suppurativa
/
Radiofrequency Therapy
Type of study:
Observational_studies
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Language:
En
Journal:
Clin Exp Dermatol
Year:
2022
Document type:
Article