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The Role of Biofactors in Diabetic Microvascular Complications.
Ziegler, Dan; Porta, Massimo; Papanas, Nikolaos; Mota, Maria; Jermendy, György; Beltramo, Elena; Mazzeo, Aurora; Caccioppo, Andrea; Striglia, Elio; Serhiyenko, Victoria; Serhiyenko, Alexandr; Rosta, László; Stirban, Ovidiu Alin; Putz, Zsuzsanna; Istenes, Ildikó; Horváth, Viktor; Kempler, Peter.
Affiliation
  • Ziegler D; Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University; Division of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.
  • Porta M; Department of Medical Sciences, University of Turin, Turin, Italy.
  • Papanas N; Diabetes Centre-Diabetic Foot Clinic, Second Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece.
  • Mota M; Department of Diabetes, Nutrition and Metabolic Diseases, University of Medicine and Pharmacy Craiova, Romania.
  • Jermendy G; Third Department of Internal Medicine, Bajcsy-Zsilinszky Hospital, Budapest, Hungary.
  • Beltramo E; Department of Medical Sciences, University of Turin, Turin, Italy.
  • Mazzeo A; Department of Medical Sciences, University of Turin, Turin, Italy.
  • Caccioppo A; Department of Medical Sciences, University of Turin, Turin, Italy.
  • Striglia E; Department of Medical Sciences, University of Turin, Turin, Italy.
  • Serhiyenko V; Department of Endocrinology, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine.
  • Serhiyenko A; Department of Endocrinology, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine.
  • Rosta L; Primary Healthcare Centre, Felsorajk, Hungary.
  • Stirban OA; Internistische Fachklinik Dr. Steger, Nürnberg, Germany.
  • Putz Z; Semmelweis University, Department of Medicine and Oncology, Budapest, Hungary.
  • Istenes I; Semmelweis University, Department of Medicine and Oncology, Budapest, Hungary.
  • Horváth V; Semmelweis University, Department of Medicine and Oncology, Budapest, Hungary.
  • Kempler P; Semmelweis University, Department of Medicine and Oncology, Budapest, Hungary.
Curr Diabetes Rev ; 18(4): e250821195830, 2022.
Article in En | MEDLINE | ID: mdl-34433401
ABSTRACT
Microvascular complications are responsible for a major proportion of the burden associated with diabetes contributing to substantial morbidity, mortality, and healthcare burden in people with diabetes. Retinopathy, nephropathy, and neuropathy constitute the leading causes of blindness, end-stage renal disease, and lower-extremity amputations, respectively. Since the efficacy of causal therapies of diabetic microvascular complications is limited, especially in type 2 diabetes, there is an unmet need for adjunct treatments which should be effective despite ongoing hyperglycemia. Experimental studies have indicated that diabetic microvascular complications can be prevented or ameliorated by various biofactors in animal models by interfering with the pathophysiology of the underlying condition. Some of the findings related to biofactors, like α-lipoic acid and benfotiamine, could be translated into the clinical arena and confirmed in clinical trials, especially in those focusing on diabetic polyneuropathy. Given the micronutrient nature of these compounds, their safety profile is excellent. Thus, they have the potential to favorably modify the natural history of the underlying complication, but long-term clinical trials are required to confirm this notion. Ultimately, biofactors should expand our therapeutic armamentarium against these common, debilitating, and even life-threatening sequelae of diabetes.
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Full text: 1 Collection: 01-internacional Health context: 6_ODS3_enfermedades_notrasmisibles Database: MEDLINE Main subject: Diabetes Mellitus, Type 2 / Diabetic Angiopathies / Diabetic Nephropathies / Diabetic Neuropathies / Diabetic Retinopathy Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: Curr Diabetes Rev Year: 2022 Document type: Article

Full text: 1 Collection: 01-internacional Health context: 6_ODS3_enfermedades_notrasmisibles Database: MEDLINE Main subject: Diabetes Mellitus, Type 2 / Diabetic Angiopathies / Diabetic Nephropathies / Diabetic Neuropathies / Diabetic Retinopathy Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: Curr Diabetes Rev Year: 2022 Document type: Article