Consequences of Paternal Nutrition on Offspring Health and Disease.
Nutrients
; 13(8)2021 Aug 17.
Article
in En
| MEDLINE
| ID: mdl-34444978
ABSTRACT
It is well established that the maternal diet during the periconceptional period affects the progeny's health. A growing body of evidence suggests that the paternal diet also influences disease onset in offspring. For many years, sperm was considered only to contribute half of the progeny's genome. It now appears that it also plays a crucial role in health and disease in offspring's adult life. The nutritional status and environmental exposure of fathers during their childhood and/or the periconceptional period have significant transgenerational consequences. This review aims to describe the effects of various human and rodent paternal feeding patterns on progeny's metabolism and health, including fasting or intermittent fasting, low-protein and folic acid deficient food, and overnutrition in high-fat and high-sugar diets. The impact on pregnancy outcome, metabolic pathways, and chronic disease onset will be described. The biological and epigenetic mechanisms underlying the transmission from fathers to their progeny will be discussed. All these data provide evidence of the impact of paternal nutrition on progeny health which could lead to preventive diet recommendations for future fathers.
Key words
Full text:
1
Collection:
01-internacional
Health context:
2_ODS3
Database:
MEDLINE
Main subject:
Pregnancy Outcome
/
Diet
/
Fathers
/
Feeding Behavior
/
Nutritional Physiological Phenomena
Limits:
Adult
/
Animals
/
Child
/
Female
/
Humans
/
Male
/
Pregnancy
Language:
En
Journal:
Nutrients
Year:
2021
Document type:
Article