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Small airway function in Finnish COVID-19 survivors.
Lindahl, Anna; Reijula, Jere; Malmberg, Leo Pekka; Aro, Miia; Vasankari, Tuula; Mäkelä, Mika Juhani.
Affiliation
  • Lindahl A; Faculty of Medicine, University of Helsinki, Helsinki, Finland. anna.lindahl@helsinki.fi.
  • Reijula J; Finnish Lung Health Association, Sibeliuksenkatu 11 A 1, 00250, Helsinki, Finland. anna.lindahl@helsinki.fi.
  • Malmberg LP; Department of Pulmonology, Helsinki University Hospital, Helsinki, Finland.
  • Aro M; Skin and Allergy Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  • Vasankari T; Finnish Lung Health Association, Sibeliuksenkatu 11 A 1, 00250, Helsinki, Finland.
  • Mäkelä MJ; Finnish Lung Health Association, Sibeliuksenkatu 11 A 1, 00250, Helsinki, Finland.
Respir Res ; 22(1): 237, 2021 Aug 26.
Article in En | MEDLINE | ID: mdl-34446020
Follow-up studies of COVID-19 patients have found lung function impairment up to six months after initial infection, but small airway function has not previously been studied. Patients (n = 20) hospitalised for a severe SARS-CoV-2 infection underwent spirometry, impulse oscillometry, and multiple measurements of alveolar nitric oxide three to six months after acute infection. None of the patients had small airway obstruction, nor increased nitric oxide concentration in the alveolar level. None of the patients had a reduced FEV1/FVC or significant bronchodilator responses in IOS or spirometry. In conclusion, we found no evidence of inflammation or dysfunction in the small airways.
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Full text: 1 Collection: 01-internacional Health context: 4_TD Database: MEDLINE Main subject: Respiratory Tract Diseases / COVID-19 Type of study: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: En Journal: Respir Res Year: 2021 Document type: Article

Full text: 1 Collection: 01-internacional Health context: 4_TD Database: MEDLINE Main subject: Respiratory Tract Diseases / COVID-19 Type of study: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: En Journal: Respir Res Year: 2021 Document type: Article