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Modeling HNF1B-associated monogenic diabetes using human iPSCs reveals an early stage impairment of the pancreatic developmental program.
El-Khairi, Ranna; Olszanowski, Evelyn; Muraro, Daniele; Madrigal, Pedro; Tilgner, Katarzyna; Chhatriwala, Mariya; Vyas, Sapna; Chia, Crystal Y; Vallier, Ludovic; Rodríguez-Seguí, Santiago A.
Affiliation
  • El-Khairi R; Wellcome Medical Research Council Cambridge Stem Cell Institute, Anne McLaren Laboratory for Regenerative Medicine, University of Cambridge, Cambridge, UK; Department of Surgery, University of Cambridge, Cambridge, UK; Wellcome Sanger Institute, Hinxton, Cambridge, UK.
  • Olszanowski E; Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE), CONICET-Universidad de Buenos Aires, Ciudad Universitaria, Buenos Aires, Argentina; Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina.
  • Muraro D; Wellcome Medical Research Council Cambridge Stem Cell Institute, Anne McLaren Laboratory for Regenerative Medicine, University of Cambridge, Cambridge, UK; Wellcome Sanger Institute, Hinxton, Cambridge, UK.
  • Madrigal P; Wellcome Medical Research Council Cambridge Stem Cell Institute, Anne McLaren Laboratory for Regenerative Medicine, University of Cambridge, Cambridge, UK; Wellcome Sanger Institute, Hinxton, Cambridge, UK.
  • Tilgner K; Wellcome Sanger Institute, Hinxton, Cambridge, UK.
  • Chhatriwala M; Wellcome Medical Research Council Cambridge Stem Cell Institute, Anne McLaren Laboratory for Regenerative Medicine, University of Cambridge, Cambridge, UK; Wellcome Sanger Institute, Hinxton, Cambridge, UK.
  • Vyas S; Wellcome Sanger Institute, Hinxton, Cambridge, UK.
  • Chia CY; Wellcome Medical Research Council Cambridge Stem Cell Institute, Anne McLaren Laboratory for Regenerative Medicine, University of Cambridge, Cambridge, UK; Wellcome Sanger Institute, Hinxton, Cambridge, UK.
  • Vallier L; Wellcome Medical Research Council Cambridge Stem Cell Institute, Anne McLaren Laboratory for Regenerative Medicine, University of Cambridge, Cambridge, UK; Wellcome Sanger Institute, Hinxton, Cambridge, UK; Department of Surgery, University of Cambridge, Cambridge, UK. Electronic address: lv225@cam.
  • Rodríguez-Seguí SA; Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE), CONICET-Universidad de Buenos Aires, Ciudad Universitaria, Buenos Aires, Argentina; Departamento de Fisiología, Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Ar
Stem Cell Reports ; 16(9): 2289-2304, 2021 09 14.
Article in En | MEDLINE | ID: mdl-34450036
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreas / Cell Differentiation / Organogenesis / Hepatocyte Nuclear Factor 1-beta / Induced Pluripotent Stem Cells / Models, Biological Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Stem Cell Reports Year: 2021 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreas / Cell Differentiation / Organogenesis / Hepatocyte Nuclear Factor 1-beta / Induced Pluripotent Stem Cells / Models, Biological Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Stem Cell Reports Year: 2021 Document type: Article