Discovery, synthesis and biological characterization of a series of <i>N</i>-(1-(1,1-dioxidotetrahydrothiophen-3-yl)-3-methyl-1<i>H</i>-pyrazol-5-yl)acetamide ethers as novel GIRK1/2 potassium channel activators.

Sharma, Swagat; Lesiak, Lauren; Aretz, Christopher D; Du, Yu; Kumar, Sushil; Gautam, Nagsen; Alnouti, Yazen; Dhuria, Nikilesh V; Chhonker, Yashpal S; Weaver, C David; Hopkins, Corey R

Discovery, synthesis and biological characterization of a series of N-(1-(1,1-dioxidotetrahydrothiophen-3-yl)-3-methyl-1H-pyrazol-5-yl)acetamide ethers as novel GIRK1/2 potassium channel activators.

Sharma, Swagat; Lesiak, Lauren; Aretz, Christopher D; Du, Yu; Kumar, Sushil; Gautam, Nagsen; Alnouti, Yazen; Dhuria, Nikilesh V; Chhonker, Yashpal S; Weaver, C David; Hopkins, Corey R.

Affiliation

Sharma S; Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center Omaha NE 68198 USA corey.hopkins@unmc.edu.
Lesiak L; Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center Omaha NE 68198 USA corey.hopkins@unmc.edu.
Aretz CD; Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center Omaha NE 68198 USA corey.hopkins@unmc.edu.
Du Y; Department of Pharmacology, Vanderbilt University School of Medicine Nashville TN 37232 USA.
Kumar S; Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center Omaha NE 68198 USA corey.hopkins@unmc.edu.
Gautam N; Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center Omaha NE 68198 USA corey.hopkins@unmc.edu.
Alnouti Y; Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center Omaha NE 68198 USA corey.hopkins@unmc.edu.
Dhuria NV; Department of Pharmacy Practice and Science, College of Pharmacy, University of Nebraska Medical Center Omaha NE 68198 USA.
Chhonker YS; Department of Pharmacy Practice and Science, College of Pharmacy, University of Nebraska Medical Center Omaha NE 68198 USA.
Weaver CD; Department of Pharmacology, Vanderbilt University School of Medicine Nashville TN 37232 USA.
Hopkins CR; Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center Omaha NE 68198 USA corey.hopkins@unmc.edu.

RSC Med Chem ; 12(8): 1366-1373, 2021 Aug 18.

Article in En | MEDLINE | ID: mdl-34458739

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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: RSC Med Chem Year: 2021 Document type: Article

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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: RSC Med Chem Year: 2021 Document type: Article