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SUPERGNOVA: local genetic correlation analysis reveals heterogeneous etiologic sharing of complex traits.
Zhang, Yiliang; Lu, Qiongshi; Ye, Yixuan; Huang, Kunling; Liu, Wei; Wu, Yuchang; Zhong, Xiaoyuan; Li, Boyang; Yu, Zhaolong; Travers, Brittany G; Werling, Donna M; Li, James J; Zhao, Hongyu.
Affiliation
  • Zhang Y; Department of Biostatistics, Yale School of Public Health, 60 College Street, New Haven, CT, 06520, USA.
  • Lu Q; Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI, 53706, USA.
  • Ye Y; Department of Statistics, University of Wisconsin-Madison, Madison, WI, 53706, USA.
  • Huang K; Center for Demography of Health and Aging, University of Wisconsin-Madison, Madison, WI, 53706, USA.
  • Liu W; Program of Computational Biology and Bioinformatics, Yale University, New Haven, CT, 06510, USA.
  • Wu Y; Department of Statistics, University of Wisconsin-Madison, Madison, WI, 53706, USA.
  • Zhong X; Program of Computational Biology and Bioinformatics, Yale University, New Haven, CT, 06510, USA.
  • Li B; Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI, 53706, USA.
  • Yu Z; Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI, 53706, USA.
  • Travers BG; Department of Biostatistics, Yale School of Public Health, 60 College Street, New Haven, CT, 06520, USA.
  • Werling DM; Program of Computational Biology and Bioinformatics, Yale University, New Haven, CT, 06510, USA.
  • Li JJ; Occupational Therapy Program in the Department of Kinesiology, University of Wisconsin-Madison, Madison, WI, 53706, USA.
  • Zhao H; Waisman Center, University of Wisconsin-Madison, Madison, WI, 53705, USA.
Genome Biol ; 22(1): 262, 2021 09 07.
Article in En | MEDLINE | ID: mdl-34493297
ABSTRACT
Local genetic correlation quantifies the genetic similarity of complex traits in specific genomic regions. However, accurate estimation of local genetic correlation remains challenging, due to linkage disequilibrium in local genomic regions and sample overlap across studies. We introduce SUPERGNOVA, a statistical framework to estimate local genetic correlations using summary statistics from genome-wide association studies. We demonstrate that SUPERGNOVA outperforms existing methods through simulations and analyses of 30 complex traits. In particular, we show that the positive yet paradoxical genetic correlation between autism spectrum disorder and cognitive performance could be explained by two etiologically distinct genetic signatures with bidirectional local genetic correlations.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Software / Quantitative Trait, Heritable / Genome-Wide Association Study Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Genome Biol Year: 2021 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Software / Quantitative Trait, Heritable / Genome-Wide Association Study Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Genome Biol Year: 2021 Document type: Article