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Identified Enrollment Challenges of Adolescent and Young Adult Patients on the Nonchemotherapy Arm of Children's Oncology Group Study ARST1321.
Avutu, Viswatej; Weiss, Aaron R; Reed, Damon R; Ahmed, Safia K; Allen-Rhoades, Wendy A; Chen, Yen-Lin E; Davis, Lara E; Eaton, Bree R; Hawkins, Douglas S; Indelicato, Danny J; Patel, Shreyaskumar R; Randall, R Lor; Reinke, Denise K; Riedel, Richard F; Scharschmidt, Thomas J; Thornton, Katherine A; Wang, Dian; Janeway, Katherine A; Kopp, Lisa M.
Affiliation
  • Avutu V; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Weiss AR; Department of Pediatrics, Maine Medical Center, Portland, Maine, USA.
  • Reed DR; Department of Individualized Cancer Management, Moffitt Cancer Center, Tampa, Florida, USA.
  • Ahmed SK; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, USA.
  • Allen-Rhoades WA; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota, USA.
  • Chen YE; Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA.
  • Davis LE; Department of Medicine, Oregon Health & Science University, Portland, Oregon, USA.
  • Eaton BR; Department of Radiation Oncology, Winship Cancer Institute of Emory University, Atlanta, Georgia, USA.
  • Hawkins DS; Department of Pediatrics, Seattle Children's Hospital, Seattle, Washington, USA.
  • Indelicato DJ; Department of Radiation Oncology, University of Florida, Jacksonville, Florida, USA.
  • Patel SR; Department of Medicine, University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.
  • Randall RL; Department of Orthopaedic Surgery, UC Davis Health, Sacramento, California, USA.
  • Reinke DK; Sarcoma Alliance for Research through Collaboration, Ann Arbor, Michigan, USA.
  • Riedel RF; Department of Medicine, Duke Cancer Institute, Durham, North Carolina, USA.
  • Scharschmidt TJ; Department of Orthopaedic Surgery, Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
  • Thornton KA; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Wang D; Department of Radiation Oncology, Rush University Medical Center, Chicago, Illinois, USA.
  • Janeway KA; Department of Pediatrics, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
  • Kopp LM; Department of Epidemiology and Biostatistics, University of Arizona, Tucson, Arizona, USA.
J Adolesc Young Adult Oncol ; 11(3): 328-332, 2022 06.
Article in En | MEDLINE | ID: mdl-34515544
ABSTRACT
ARST1321, a trial of patients with advanced soft tissue sarcoma, was the first National Clinical Trials Network study codeveloped by pediatric and adult consortia with two treatment cohorts. We report on the findings of a survey to identify barriers to enrolling adolescent and young adult patients (15-39 years) onto the nonchemotherapy arm. The survey response rate was 31% with a 70% completion rate. Common identified reasons for low accrual in order of decreasing frequency included insufficient funding, lack of study awareness or interest, competing trials, toxicity concerns, philosophical differences in the therapy backbone, and regulatory and infrastructure barriers. Clinical Trials.gov ID NCT02180867.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Patient Participation / Sarcoma / Soft Tissue Neoplasms / Clinical Trials as Topic Type of study: Prognostic_studies Aspects: Patient_preference Limits: Adolescent / Adult / Humans Language: En Journal: J Adolesc Young Adult Oncol Year: 2022 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Patient Participation / Sarcoma / Soft Tissue Neoplasms / Clinical Trials as Topic Type of study: Prognostic_studies Aspects: Patient_preference Limits: Adolescent / Adult / Humans Language: En Journal: J Adolesc Young Adult Oncol Year: 2022 Document type: Article