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Discovery of highly potent human glutaminyl cyclase (QC) inhibitors as anti-Alzheimer's agents by the combination of pharmacophore-based and structure-based design.
Van Manh, Nguyen; Hoang, Van-Hai; Ngo, Van T H; Ann, Jihyae; Jang, Tae-Ho; Ha, Jung-Hye; Song, Jae Young; Ha, Hee-Jin; Kim, Hee; Kim, Young-Ho; Lee, Jiyoun; Lee, Jeewoo.
Affiliation
  • Van Manh N; Laboratory of Medicinal Chemistry, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 08826, Republic of Korea.
  • Hoang VH; Laboratory of Medicinal Chemistry, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 08826, Republic of Korea.
  • Ngo VTH; Laboratory of Medicinal Chemistry, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 08826, Republic of Korea; Graduate Department of Healthcare Science, Dainam University, Hanoi, Viet Nam.
  • Ann J; Laboratory of Medicinal Chemistry, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 08826, Republic of Korea.
  • Jang TH; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, 41061, Republic of Korea.
  • Ha JH; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, 41061, Republic of Korea.
  • Song JY; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, 41061, Republic of Korea.
  • Ha HJ; Medifron DBT, Seoul, 08502, Republic of Korea.
  • Kim H; Medifron DBT, Seoul, 08502, Republic of Korea.
  • Kim YH; Medifron DBT, Seoul, 08502, Republic of Korea.
  • Lee J; Department of Global Medical Science, Sungshin University, Seoul, 01133, Republic of Korea.
  • Lee J; Laboratory of Medicinal Chemistry, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 08826, Republic of Korea. Electronic address: jeewoo@snu.ac.kr.
Eur J Med Chem ; 226: 113819, 2021 Dec 15.
Article in En | MEDLINE | ID: mdl-34536669
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzimidazoles / Neuroprotective Agents / Aminoacyltransferases / Cyclopentanes / Enzyme Inhibitors / Alzheimer Disease Limits: Animals / Humans / Male Language: En Journal: Eur J Med Chem Year: 2021 Document type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzimidazoles / Neuroprotective Agents / Aminoacyltransferases / Cyclopentanes / Enzyme Inhibitors / Alzheimer Disease Limits: Animals / Humans / Male Language: En Journal: Eur J Med Chem Year: 2021 Document type: Article