The NLRP3 inhibitor dapansutrile attenuates folic acid induced nephrotoxicity via inhibiting inflammasome/caspase-1/IL axis and regulating autophagy/proliferation.

Elsayed, Mohamed S; Abu-Elsaad, Nashwa M; Nader, Manar A

Elsayed, Mohamed S; Abu-Elsaad, Nashwa M; Nader, Manar A.

Affiliation

Elsayed MS; Pharmacology and Toxicology Dep., Faculty of Pharmacy, Mansoura University, Egypt.
Abu-Elsaad NM; Pharmacology and Toxicology Dep., Faculty of Pharmacy, Mansoura University, Egypt. Electronic address: nashabuelsaad@mans.edu.eg.
Nader MA; Pharmacology and Toxicology Dep., Faculty of Pharmacy, Mansoura University, Egypt.

Life Sci ; 285: 119974, 2021 Nov 15.

Article in En | MEDLINE | ID: mdl-34560082

Subject(s)

Acute Kidney Injury/drug therapy; Anti-Inflammatory Agents/therapeutic use; Caspase 1/metabolism; Folic Acid/toxicity; Inflammasomes/antagonists & inhibitors; NLR Family, Pyrin Domain-Containing 3 Protein/antagonists & inhibitors; Nitriles/therapeutic use; Acute Kidney Injury/chemically induced; Animals; Anti-Inflammatory Agents/pharmacology; Autophagy/drug effects; Biomarkers; Cell Proliferation; Interleukin-18/antagonists & inhibitors; Interleukin-18/metabolism; Interleukin-1beta/antagonists & inhibitors; Interleukin-1beta/metabolism; Ki-67 Antigen/metabolism; Kidney/drug effects; Male; Nitriles/pharmacology; Rats; Rats, Sprague-Dawley

Key words

Caspase-1; Inflammasome; Ki-67; LC-3; Nephrotoxicity

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Caspase 1 / Acute Kidney Injury / Inflammasomes / Folic Acid / NLR Family, Pyrin Domain-Containing 3 Protein / Anti-Inflammatory Agents / Nitriles Type of study: Guideline Limits: Animals Language: En Journal: Life Sci Year: 2021 Document type: Article

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