Scalable Asymmetric Synthesis of MK-8998, a T-Type Calcium Channel Antagonist.
J Org Chem
; 87(4): 2120-2128, 2022 02 18.
Article
in En
| MEDLINE
| ID: mdl-34582192
ABSTRACT
Two scalable and efficient synthetic routes for the synthesis of a T-type calcium channel antagonist MK-8998 were developed from a simple pyridine building block. The key step to set the stereochemistry relied on either chiral rhodium catalyst-mediated asymmetric hydrogenation of an enamide or transamination of an arylketone that provided the corresponding product in high enantioselectivity and high yield.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Rhodium
/
Calcium Channel Blockers
Language:
En
Journal:
J Org Chem
Year:
2022
Document type:
Article