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SARS-CoV-2 inhibition using a mucoadhesive, amphiphilic chitosan that may serve as an anti-viral nasal spray.
Pyrc, Krzysztof; Milewska, Aleksandra; Duran, Emilia Barreto; Botwina, Pawel; Dabrowska, Agnieszka; Jedrysik, Malwina; Benedyk, Malgorzata; Lopes, Rui; Arenas-Pinto, Alejandro; Badr, Moutaz; Mellor, Ryan; Kalber, Tammy L; Fernandez-Reyes, Delmiro; Schätzlein, Andreas G; Uchegbu, Ijeoma F.
Affiliation
  • Pyrc K; Laboratory of Virology and ABSL3 Animal Facility at the Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30-387, Krakow, Poland.
  • Milewska A; Laboratory of Virology and ABSL3 Animal Facility at the Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30-387, Krakow, Poland.
  • Duran EB; Laboratory of Virology and ABSL3 Animal Facility at the Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30-387, Krakow, Poland.
  • Botwina P; Laboratory of Virology and ABSL3 Animal Facility at the Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30-387, Krakow, Poland.
  • Dabrowska A; Microbiology Department, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387, Krakow, Poland.
  • Jedrysik M; Laboratory of Virology and ABSL3 Animal Facility at the Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30-387, Krakow, Poland.
  • Benedyk M; Microbiology Department, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387, Krakow, Poland.
  • Lopes R; Nanomerics Ltd., 6th Floor, 2 London Wall Place, London, EC2Y 5AU, UK.
  • Arenas-Pinto A; UCL School of Pharmacy, 29-39 Brunswick Square, London, WC1N 1AX, UK.
  • Badr M; Centre for Clinical Research in Infection and Sexual Health, UCL Institute for Global Health, Mortimer Market Centre, off Capper Street, London, WC1E 6JB, UK.
  • Mellor R; MRC-Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, 90 High Holborn, London, WC1V 6LJ, UK.
  • Kalber TL; Nanomerics Ltd., 6th Floor, 2 London Wall Place, London, EC2Y 5AU, UK.
  • Fernandez-Reyes D; UCL School of Pharmacy, 29-39 Brunswick Square, London, WC1N 1AX, UK.
  • Schätzlein AG; Nanomerics Ltd., 6th Floor, 2 London Wall Place, London, EC2Y 5AU, UK.
  • Uchegbu IF; UCL School of Pharmacy, 29-39 Brunswick Square, London, WC1N 1AX, UK.
Sci Rep ; 11(1): 20012, 2021 10 08.
Article in En | MEDLINE | ID: mdl-34625610
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Nasal Sprays / SARS-CoV-2 / COVID-19 Drug Treatment Limits: Animals / Humans / Male Language: En Journal: Sci Rep Year: 2021 Document type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Nasal Sprays / SARS-CoV-2 / COVID-19 Drug Treatment Limits: Animals / Humans / Male Language: En Journal: Sci Rep Year: 2021 Document type: Article