In vivo Study of a Newly Synthesized Chromen-4-one Derivative as an Antitumor Agent against HCC.

Nabeel, Asmaa I; Mansour, Somaya Z; Mahdy, El-Sayed M E; El-Mezayen, Hatem A; Mohamed, Sarah A

Nabeel, Asmaa I; Mansour, Somaya Z; Mahdy, El-Sayed M E; El-Mezayen, Hatem A; Mohamed, Sarah A.

Affiliation

Nabeel AI; Biochemistry Lab Chemistry Department Faculty of Education, Ain Shams University, Cairo, Egypt. asmaa.nabeel@hotmail.com.
Mansour SZ; Department of Radiation Biology, National Center of Radiation Research and Technology, Atomic Energy Authority, Cairo, Egypt.
El-Mezayen HA; Department of Chemistry, Faculty of Science, Helwan University, Cairo, Egypt.
Mohamed SA; Chemistry Administration, Cairo, Egypt.

J Gastrointest Cancer ; 53(4): 980-989, 2022 Dec.

Article in En | MEDLINE | ID: mdl-34698995

Subject(s)

Antineoplastic Agents; Carcinoma, Hepatocellular; Liver Neoplasms; Animals; Humans; Rats; Anti-Inflammatory Agents/pharmacology; Antineoplastic Agents/chemistry; Antineoplastic Agents/pharmacology; Antioxidants/pharmacology; bcl-2-Associated X Protein; Benzopyrans/pharmacology; Carcinoma, Hepatocellular/pathology; Diethylnitrosamine/adverse effects; Liver Neoplasms/pathology; Matrix Metalloproteinase 9/metabolism; Proto-Oncogene Proteins c-bcl-2/metabolism; Tumor Necrosis Factor-alpha/metabolism; Tumor Suppressor Protein p53/metabolism; Vascular Endothelial Growth Factor A/metabolism

Key words

Bcl2Bax; Chromene derivative; Cyt C; HCC; MMP-9; TNF-α; VEGF; p53

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carcinoma, Hepatocellular / Liver Neoplasms / Antineoplastic Agents Limits: Animals / Humans Language: En Journal: J Gastrointest Cancer Year: 2022 Document type: Article

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