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Chromatin-state barriers enforce an irreversible mammalian cell fate decision.
Blanco, M Andrés; Sykes, David B; Gu, Lei; Wu, Mengjun; Petroni, Ricardo; Karnik, Rahul; Wawer, Mathias; Rico, Joshua; Li, Haitao; Jacobus, William D; Jambhekar, Ashwini; Cheloufi, Sihem; Meissner, Alexander; Hochedlinger, Konrad; Scadden, David T; Shi, Yang.
Affiliation
  • Blanco MA; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA; Division of Newborn Medicine, Boston Children's Hospital, Boston, MA, USA; Department of Cell Biology, Harvard Medical School, Boston, MA, USA. Electronic address: ablanco@vet.upenn.e
  • Sykes DB; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, USA; Harvard Stem Cell Institute, Cambridge, MA, USA.
  • Gu L; Division of Newborn Medicine, Boston Children's Hospital, Boston, MA, USA; Department of Cell Biology, Harvard Medical School, Boston, MA, USA; Cardiopulmonary Institute (CPI), Bad Nauheim, Germany; Epigenetics Laboratory, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.
  • Wu M; Division of Newborn Medicine, Boston Children's Hospital, Boston, MA, USA; Department of Cell Biology, Harvard Medical School, Boston, MA, USA.
  • Petroni R; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Karnik R; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Harvard Stem Cell Institute, Cambridge, MA, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
  • Wawer M; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Rico J; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Li H; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Jacobus WD; Division of Newborn Medicine, Boston Children's Hospital, Boston, MA, USA; Department of Cell Biology, Harvard Medical School, Boston, MA, USA.
  • Jambhekar A; Division of Newborn Medicine, Boston Children's Hospital, Boston, MA, USA; Department of Cell Biology, Harvard Medical School, Boston, MA, USA.
  • Cheloufi S; Department of Biochemistry, Stem Cell Center, University of California, Riverside, Riverside, CA, USA.
  • Meissner A; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Harvard Stem Cell Institute, Cambridge, MA, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA; Department of Genome Regulation, Max Planck Institute for Molecular Genetics, Berlin, Germany.
  • Hochedlinger K; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Harvard Stem Cell Institute, Cambridge, MA, USA; Department of Molecular Biology and Cancer Center, Massachusetts General Hospital, Boston, MA, USA.
  • Scadden DT; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, USA; Harvard Stem Cell Institute, Cambridge, MA, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA. Electronic address: david_scadden@harvard.edu.
  • Shi Y; Division of Newborn Medicine, Boston Children's Hospital, Boston, MA, USA; Ludwig Institute for Cancer Research, Oxford Branch, Oxford University, Oxford, UK. Electronic address: yang.shi@ludwig.ox.ac.uk.
Cell Rep ; 37(6): 109967, 2021 11 09.
Article in En | MEDLINE | ID: mdl-34758323
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / Bone Marrow / Hematopoietic Stem Cells / Chromatin / Cell Lineage / Myeloid Cells / Hematopoiesis Type of study: Prognostic_studies Limits: Animals Language: En Journal: Cell Rep Year: 2021 Document type: Article
Fulltext
Print
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / Bone Marrow / Hematopoietic Stem Cells / Chromatin / Cell Lineage / Myeloid Cells / Hematopoiesis Type of study: Prognostic_studies Limits: Animals Language: En Journal: Cell Rep Year: 2021 Document type: Article