Loss of &#945;-actinin-3 confers protection from eccentric contraction damage in fast-twitch EDL muscles from aged mdx dystrophic mice by reducing pathological fibre branching.

Kiriaev, Leonit; Houweling, Peter J; North, Kathryn N; Head, Stewart I

Loss of α-actinin-3 confers protection from eccentric contraction damage in fast-twitch EDL muscles from aged mdx dystrophic mice by reducing pathological fibre branching.

Kiriaev, Leonit; Houweling, Peter J; North, Kathryn N; Head, Stewart I.

Affiliation

Kiriaev L; School of Medicine, Western Sydney University, Sydney, NSW 2560, Australia.
Houweling PJ; Murdoch Children's Research Institute, Melbourne, Victoria 3052, Australia.
North KN; Department of Paediatrics, University of Melbourne, Melbourne, Victoria 3052, Australia.
Head SI; Murdoch Children's Research Institute, Melbourne, Victoria 3052, Australia.

Hum Mol Genet ; 31(9): 1417-1429, 2022 05 04.

Article in En | MEDLINE | ID: mdl-34761268

Subject(s)

Dystrophin; Muscular Dystrophy, Duchenne; Actinin/genetics; Actinin/metabolism; Aged; Animals; Dystrophin/metabolism; Humans; Mice; Mice, Inbred mdx; Muscle Contraction/genetics; Muscle Fibers, Skeletal/metabolism; Muscle, Skeletal/metabolism; Muscular Dystrophy, Duchenne/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Dystrophin / Muscular Dystrophy, Duchenne Type of study: Prognostic_studies Limits: Aged / Animals / Humans Language: En Journal: Hum Mol Genet Year: 2022 Document type: Article

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