Aryl Hydrocarbon Receptor (AhR) Activation by 2,3,7,8-Tetrachlorodibenzo-<i>p</i>-Dioxin (TCDD) Dose-Dependently Shifts the Gut Microbiome Consistent with the Progression of Non-Alcoholic Fatty Liver Disease.

Fling, Russell R; Zacharewski, Timothy R

Aryl Hydrocarbon Receptor (AhR) Activation by 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) Dose-Dependently Shifts the Gut Microbiome Consistent with the Progression of Non-Alcoholic Fatty Liver Disease.

Fling, Russell R; Zacharewski, Timothy R.

Affiliation

Fling RR; Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824, USA.
Zacharewski TR; Institute for Integrative Toxicology, Michigan State University, East Lansing, MI 48824, USA.

Int J Mol Sci ; 22(22)2021 Nov 18.

Article in En | MEDLINE | ID: mdl-34830313

Subject(s)

Basic Helix-Loop-Helix Transcription Factors/genetics; Dysbiosis/genetics; Gastrointestinal Microbiome/drug effects; Non-alcoholic Fatty Liver Disease/genetics; Polychlorinated Dibenzodioxins/pharmacology; Receptors, Aryl Hydrocarbon/genetics; Animals; Bacteroidetes/genetics; Bacteroidetes/growth & development; Bacteroidetes/isolation & purification; Basic Helix-Loop-Helix Transcription Factors/agonists; Basic Helix-Loop-Helix Transcription Factors/metabolism; Dysbiosis/chemically induced; Dysbiosis/metabolism; Dysbiosis/pathology; Gastrointestinal Microbiome/genetics; Gene Expression Regulation; Humans; Lactobacillus/classification; Lactobacillus/genetics; Lactobacillus/growth & development; Lactobacillus/isolation & purification; Liver/drug effects; Liver/metabolism; Liver/pathology; Liver Cirrhosis/genetics; Liver Cirrhosis/metabolism; Liver Cirrhosis/pathology; Male; Metabolic Networks and Pathways/genetics; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease/chemically induced; Non-alcoholic Fatty Liver Disease/metabolism; Non-alcoholic Fatty Liver Disease/pathology; Receptors, Aryl Hydrocarbon/agonists; Receptors, Aryl Hydrocarbon/metabolism

Key words

2,3,7,8-tetrachlorodibenzo-p-dioxin; aryl hydrocarbon receptor; dioxin; fibrosis; gut dysbiosis; gut microbiome; non-alcoholic fatty liver disease; secondary bile acids

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Full text: 1 Collection: 01-internacional Health context: 3_ND Database: MEDLINE Main subject: Receptors, Aryl Hydrocarbon / Basic Helix-Loop-Helix Transcription Factors / Dysbiosis / Non-alcoholic Fatty Liver Disease / Gastrointestinal Microbiome / Polychlorinated Dibenzodioxins Type of study: Prognostic_studies Language: En Journal: Int J Mol Sci Year: 2021 Document type: Article

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