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Loss of MED12 activates the TGFß pathway to promote chemoresistance and replication fork stability in BRCA-deficient cells.
Jackson, Lindsey M; Dhoonmoon, Ashna; Hale, Anastasia; Dennis, Kady A; Schleicher, Emily M; Nicolae, Claudia M; Moldovan, George-Lucian.
Affiliation
  • Jackson LM; Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
  • Dhoonmoon A; Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
  • Hale A; Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
  • Dennis KA; Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
  • Schleicher EM; Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
  • Nicolae CM; Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
  • Moldovan GL; Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Nucleic Acids Res ; 49(22): 12855-12869, 2021 12 16.
Article in En | MEDLINE | ID: mdl-34871431
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transforming Growth Factor beta / Drug Resistance, Neoplasm / BRCA1 Protein / BRCA2 Protein / DNA Replication / Mediator Complex Type of study: Prognostic_studies Limits: Humans Language: En Journal: Nucleic Acids Res Year: 2021 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transforming Growth Factor beta / Drug Resistance, Neoplasm / BRCA1 Protein / BRCA2 Protein / DNA Replication / Mediator Complex Type of study: Prognostic_studies Limits: Humans Language: En Journal: Nucleic Acids Res Year: 2021 Document type: Article