Restraint stress potentiates neuropeptide Y-mediated impairment on spatial memory in rats.
Behav Brain Res
; 419: 113705, 2022 02 15.
Article
in En
| MEDLINE
| ID: mdl-34871704
ABSTRACT
Memory is the ability to store, retrieve and use information that requires a progressive time-dependent stabilization process known as consolidation to be established. The hippocampus is essential for processing all the information that forms memory, especially spatial memory. Neuropeptide Y (NPY) affects memory, so in this study we investigated the participation and recruitment of NPY receptors during spatial memory consolidation in rats. Using the water maze test, we show that NPY (1 pmol) injected into the dorsal hippocampus impaired memory consolidation and that previous restraint stress (30 min) potentiates NPY effects, i.e. further impaired memory consolidation. Using selective antagonists for NPY Y1 and Y2 receptors we demonstrate that both receptors play a key role on spatial memory consolidation. Our data suggest that NPY modulates aversive and adaptive memory formation by NPY receptors activation.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Stress, Psychological
/
Behavior, Animal
/
Neuropeptide Y
/
Receptors, Neuropeptide Y
/
Spatial Memory
/
Memory Disorders
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Behav Brain Res
Year:
2022
Document type:
Article