Red flags of poor prognosis in pediatric cases of COVID-19: the first 6610 hospitalized children in Iran.
BMC Pediatr
; 21(1): 563, 2021 12 10.
Article
in En
| MEDLINE
| ID: mdl-34893036
ABSTRACT
INTRODUCTION:
COVID-19 clinical course, effective therapeutic regimen, and poor prognosis risk factors in pediatric cases are still under investigation and no approved vaccinehas been introduced for them.METHODS:
This cross-sectional study evaluated different aspect of COVID-19 infection in hospitalized COVID-19 positive children (âº18 years oldwith laboratory confirmed COVID-19 infection, using the national COVID-19 registry for all admitted COVID-19 positive cases from February 19 until November 13,2020, in Iran.RESULTS:
We evaluated 6610 hospitalized children. Fifty-four percent (3268) were male and one third of them were infants younger than 1 year. Mortality rate in total hospitalized children was 5.3% and in children with underlying co-morbidities (14.4%) was significantly higher (OR 3.6 [2.7-4.7]). Chronic kidney disease (OR 3.42 [1.75-6.67]), Cardiovascular diseases (OR 3.2 [2.09-5.11]), chronic pulmonary diseases (OR 3.21 [1.59-6.47]), and diabetes mellitus (OR 2.5 [1.38-4.55]), resulted in higher mortality rates in hospitalized COVID-19 children. Fever (41%), cough (36%), and dyspnea (27%) were the most frequent symptoms in hospitalized children and dyspnea was associated with near three times higher mortality rate among children with COVID-19 infection (OR 2.65 [2.13-3.29]).CONCLUSION:
Iran has relatively high COVID-19 mortality in hospitalized children. Pediatricians should consider children presenting with dyspnea, infants⺠1 year and children with underlying co-morbidities, as high-risk groups for hospitalization, ICU admission, and death.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
COVID-19
Type of study:
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Child
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
En
Journal:
BMC Pediatr
Year:
2021
Document type:
Article