DNA-PKcs: A Targetable Protumorigenic Protein Kinase.
Cancer Res
; 82(4): 523-533, 2022 02 15.
Article
in En
| MEDLINE
| ID: mdl-34893509
ABSTRACT
DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is a pleiotropic protein kinase that plays critical roles in cellular processes fundamental to cancer. DNA-PKcs expression and activity are frequently deregulated in multiple hematologic and solid tumors and have been tightly linked to poor outcome. Given the potentially influential role of DNA-PKcs in cancer development and progression, therapeutic targeting of this kinase is being tested in preclinical and clinical settings. This review summarizes the latest advances in the field, providing a comprehensive discussion of DNA-PKcs functions in cancer and an update on the clinical assessment of DNA-PK inhibitors in cancer therapy.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Protein Biosynthesis
/
Gene Expression Regulation, Neoplastic
/
Energy Metabolism
/
DNA-Activated Protein Kinase
/
Immunity
/
Neoplasms
Limits:
Animals
/
Humans
Language:
En
Journal:
Cancer Res
Year:
2022
Document type:
Article