Components of the phosphatidylserine endoplasmic reticulum to plasma membrane transport mechanism as targets for KRAS inhibition in pancreatic cancer.

Kattan, Walaa E; Liu, Junchen; Montufar-Solis, Dina; Liang, Hong; Brahmendra Barathi, Bhargavi; van der Hoeven, Ransome; Zhou, Yong; Hancock, John F

Kattan, Walaa E; Liu, Junchen; Montufar-Solis, Dina; Liang, Hong; Brahmendra Barathi, Bhargavi; van der Hoeven, Ransome; Zhou, Yong; Hancock, John F.

Affiliation

Kattan WE; Department of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center, Houston, TX 77030.
Liu J; Cancer Biology Program, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences at Houston, Houston, TX 77030.
Montufar-Solis D; Department of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center, Houston, TX 77030.
Liang H; Department of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center, Houston, TX 77030.
Brahmendra Barathi B; Department of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center, Houston, TX 77030.
van der Hoeven R; Cancer Biology Program, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences at Houston, Houston, TX 77030.
Zhou Y; Department of Diagnostic and Biomedical Sciences, School of Dentistry, University of Texas Health Science Center, Houston, TX 77054.
Hancock JF; Department of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center, Houston, TX 77030.

Proc Natl Acad Sci U S A ; 118(51)2021 12 21.

Article in En | MEDLINE | ID: mdl-34903667

Subject(s)

Antineoplastic Agents/pharmacology; Cell Membrane/metabolism; Endoplasmic Reticulum/metabolism; Phosphatidylserines/metabolism; Proto-Oncogene Proteins p21(ras)/antagonists & inhibitors; Receptors, Steroid/metabolism; 1-Phosphatidylinositol 4-Kinase/antagonists & inhibitors; 1-Phosphatidylinositol 4-Kinase/genetics; 1-Phosphatidylinositol 4-Kinase/metabolism; Adaptor Proteins, Signal Transducing/genetics; Adaptor Proteins, Signal Transducing/metabolism; Animals; Biological Transport/drug effects; Cell Line, Tumor; Drug Delivery Systems; Gene Knockdown Techniques; Humans; Mice; Mice, Nude; Protease Inhibitors/pharmacology; Proto-Oncogene Proteins p21(ras)/genetics; Proto-Oncogene Proteins p21(ras)/metabolism; Receptors, Steroid/genetics; Simeprevir/pharmacology; Xenograft Model Antitumor Assays

Key words

KRAS; ORP5; ORP8; PI4KA; phosphatidylserine

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphatidylserines / Receptors, Steroid / Cell Membrane / Proto-Oncogene Proteins p21(ras) / Endoplasmic Reticulum / Antineoplastic Agents Limits: Animals / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2021 Document type: Article

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