The atomic portrait of SARS-CoV-2 as captured by cryo-electron microscopy.

Fertig, Tudor Emanuel; Chitoiu, Leona; Terinte-Balcan, George; Peteu, Victor-Eduard; Marta, Daciana; Gherghiceanu, Mihaela

Fertig, Tudor Emanuel; Chitoiu, Leona; Terinte-Balcan, George; Peteu, Victor-Eduard; Marta, Daciana; Gherghiceanu, Mihaela.

Affiliation

Fertig TE; Ultrastructural Pathology and Bioimaging Lab, Victor BabeÈ National Institute of Pathology, Bucharest, Romania.
Chitoiu L; Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
Terinte-Balcan G; Ultrastructural Pathology and Bioimaging Lab, Victor BabeÈ National Institute of Pathology, Bucharest, Romania.
Peteu VE; Ultrastructural Pathology and Bioimaging Lab, Victor BabeÈ National Institute of Pathology, Bucharest, Romania.
Marta D; Ultrastructural Pathology and Bioimaging Lab, Victor BabeÈ National Institute of Pathology, Bucharest, Romania.
Gherghiceanu M; Ultrastructural Pathology and Bioimaging Lab, Victor BabeÈ National Institute of Pathology, Bucharest, Romania.

J Cell Mol Med ; 26(1): 25-34, 2022 01.

Article in En | MEDLINE | ID: mdl-34904376

Subject(s)

Angiotensin-Converting Enzyme 2/chemistry; Antibodies, Viral/chemistry; COVID-19 Vaccines/chemistry; COVID-19/prevention & control; Receptors, Virus/chemistry; Spike Glycoprotein, Coronavirus/chemistry; Angiotensin-Converting Enzyme 2/immunology; Angiotensin-Converting Enzyme 2/metabolism; Antibodies, Viral/biosynthesis; COVID-19/immunology; COVID-19/virology; COVID-19 Vaccines/administration & dosage; COVID-19 Vaccines/biosynthesis; Cryoelectron Microscopy; Epitopes/chemistry; Epitopes/immunology; Epitopes/metabolism; Humans; Models, Molecular; Protein Binding; Protein Interaction Domains and Motifs; Protein Structure, Secondary; Receptors, Virus/immunology; Receptors, Virus/metabolism; SARS-CoV-2/drug effects; SARS-CoV-2/pathogenicity; SARS-CoV-2/ultrastructure; Serine Endopeptidases/chemistry; Serine Endopeptidases/immunology; Serine Endopeptidases/metabolism; Spike Glycoprotein, Coronavirus/immunology; Spike Glycoprotein, Coronavirus/metabolism; Virion/drug effects; Virion/pathogenicity; Virion/ultrastructure

Key words

COVID-19; SARS-CoV-2; cryo-electron microscopy; cryo-electron tomography; single-particle analysis; structural biology

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Full text: 1 Collection: 01-internacional Health context: 4_TD / 6_ODS3_enfermedades_notrasmisibles Database: MEDLINE Main subject: Receptors, Virus / Spike Glycoprotein, Coronavirus / Angiotensin-Converting Enzyme 2 / COVID-19 Vaccines / COVID-19 / Antibodies, Viral Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Cell Mol Med Year: 2022 Document type: Article

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