Targeting intracellular protein-protein interactions with macrocyclic peptides.

Buyanova, Marina; Pei, Dehua

Buyanova, Marina; Pei, Dehua.

Affiliation

Buyanova M; Department of Chemistry and Biochemistry, The Ohio State University, 484 West 12th Avenue, Columbus, OH 43210, USA.
Pei D; Department of Chemistry and Biochemistry, The Ohio State University, 484 West 12th Avenue, Columbus, OH 43210, USA. Electronic address: pei.3@osu.edu.

Trends Pharmacol Sci ; 43(3): 234-248, 2022 03.

Article in En | MEDLINE | ID: mdl-34911657

Subject(s)

Peptides, Cyclic; Peptides; Animals; Cell Membrane/metabolism; Endocytosis; Endosomes/metabolism; Humans; Mammals/metabolism; Peptides, Cyclic/metabolism; Peptides, Cyclic/pharmacology

Key words

bicyclic peptide; cyclic peptide; drug discovery; intracellular biologics; permeability; protein-protein interaction

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Peptides, Cyclic Limits: Animals / Humans Language: En Journal: Trends Pharmacol Sci Year: 2022 Document type: Article

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